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Table 1 Percent changes in mRNA from C7/C8/T1 DRGs in male and female mice

From: Sex differences in primary muscle afferent sensitization following ischemia and reperfusion injury

Gene Naïve female expression I/R-induced upregulation Two-way comparisons
(Relative to naïve males) Male Female Injury Sex Interaction
ASIC1 15.3 ± 17% 77.1 ± 13% * 34.8 ± 17% < 0.001 0.955 0.193
ASIC3 − 9.7 ± 12% 85.0 ± 9% * 10.6 ± 11% < 0.001 < 0.001 0.002
IL1r1 − 10.1 ± 17% 74.0 ± 10% * 95.0 ± 23% * < 0.001 0.698 0.659
P2X3 − 59.7 ± 29% * 75.8 ± 23% * 181.9 ± 21%* < 0.001 < 0.001 0.112
P2X5 − 33.7 ± 18% 50.2 ± 8% * 63.2 ± 22% * < 0.001 0.004 0.740
TRPM8 − 46.4 ± 20% * 17.8 ± 19% 93.4 ± 24% * 0.005 0.01 0.085
TRPV1 − 40.1 ± 14% * 42.3 ± 23% 133.7 ± 17% * < 0.001 0.078 0.098
  1. Values indicate percentage change in mRNA expression of naïve females relative to naïve males and 1d I/R animals of both sexes relative to sex- and age-matched naïve controls ± error of the difference in means (n = 4–11 per condition). Final * P < .05 obtained via false discovery rate correction following two-way ANOVA on raw sample ∆Cts