Fig. 3
Venn diagrams showing the distribution of differentially expressed SP-A1 and SP-A2 AM miRNAs that changed ≥ 2-fold compared to SP-A KO AM, which are unique or common (overlapping areas) in FA and O3 exposure. Also, the figure shows the effect of sex on the expression of miRNAs after FA and O3 exposure. Venn diagrams are showing unique and commonly identified miRNAs among SP-A1 and SP-A2 male and female hTG mice. Out of the total 226 miRNAs identified in male and female SP-A1, 49 identified miRNAs are unique to male and 24 are unique to female; 153 miRNAs are identified in common after O3 exposure. In the case of SP-A2, out of the 166 miRNAs identified, 48 miRNAs are unique to male and 100 are unique to female; 18 miRNAs were identified in common after O3 exposure. However, under control conditions, more miRNAs (n = 122) were in common in the SP-A1 male and female mice than in the SP-A2 (n = 24)