Stress amplifies sex differences in primate prefrontal profiles of gene expression

Table 2 Top 25 genes with the largest disparity in effect sizes for sex differences in stress versus no-stress conditions. Effect sizes (η ²) for sex differences in stress and no-stress conditions are presented for ventrolateral (vlPFC) and ventromedial (vmPFC) prefrontal cortical regions. F > M signifies genes with greater expression in females compared to males, and M > F signifies the reverse

Gene	Biological function	vlPFC		vmPFC		Effect direction
Gene	Biological function	Stress	No-stress	Stress	No-stress	Effect direction
MAP3K4	MAPK signaling	0.65	0.11	0.57	0.05	F < M
CRKL		0.66	0.13	0.59	0.16	F < M
TRAF6		0.30	0.18	0.73	0.11	F < M
SLC6A1	Transporter activity	0.69	0.33	0.80	0.26	F < M
SLC24A2		0.30	0.08	0.63	0.12	F < M
SLC44A1		0.71	0.30	0.30	<0.01	F < M
KCNIP1		0.40	0.07	0.75	0.08	F < M
TSC22D3		0.56	0.15	0.58	0.07	F < M
HHIP	Brain development	0.57	0.10	0.39	0.02	F < M
SPRY4		0.80	0.33	0.47	0.06	F < M
MEIS1		0.47	<0.01	0.72	0.07	F < M
ARCN1		0.56	0.31	0.76	0.18	F < M
DET1	Protein assembly	0.78	0.04	0.49	0.01	F< M
RBBP5		0.38	0.02	0.70	0.03	F < M
TRIM4		0.71	0.14	0.46	0.32	F < M
ZDHHC6	Catalytic activity	0.84	0.26	0.83	0.44	F < M
ABCF2		0.51	0.05	0.52	0.10	F < M
HELQ		0.60	0.18	0.69	0.35	F < M
WDR33	RNA processing	0.69	0.16	0.66	0.21	F < M
RBMS1	RNA processing	0.59	0.34	0.78	0.05	F < M
CLDND2	Miscellaneous	0.72	0.16	0.80	0.09	M > F
LRCH1		0.84	0.16	0.85	0.31	F < M
TM9SF1		0.69	0.11	0.57	0.09	F < M
ANKRD37		0.69	0.05	0.62	0.23	F < M
CAP1		0.54	0.28	0.41	0.10	F < M

ISSN: 2042-6410