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Fig. 8 | Biology of Sex Differences

Fig. 8

From: Sex chromosomes drive gene expression and regulatory dimorphisms in mouse embryonic stem cells

Fig. 8

Differential gene expression analysis across karyotypes. a Expression comparisons between XX, XY, and XO ES cell lines, showing the extent of shared differences in pair-wise comparisons for X-linked and autosomal genes. b Gene ontology of genes showing X chromosome dependency, Y chromosome dependency, and aneuploidy-specific effects. Genes showing X chromosome dependency, aneuploidy-specific effects, or Y chromosome-dependency fall within unique ontology terms. Visualization performed using the GO-plot package in R. The outer circle shows a scatter plot of the log-fold change for the assigned genes within each distinct gene ontology term. Selection for enrichment resulted in blue dots only, which indicate upregulation. The inner circle is a bar plot with the height of the bar illustrating the p value of the term and the color representing the z-score, which evaluates the direction of the fold change of each of the genes within the assigned term and provides a relative scale for enrichment

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