Table 3 Distribution of key ion channel proteins in human myocardium and calculations regarding base-apex differences

Protein

Base

Apex

% Difference

P value

Cav1.2α

0.49 ± 0.1

0.47 ± 0.1

4.1%

1.0000

0.57 ± 0.12

0.38 ± 0.09

48.8%*

0.0002

0.74 ± 0.25

0.59 ± 0.17

24.1%

0.5625

NCX1

0.71 ± 0.07

0.64 ± 0.13

10.9%

0.6875

0.68 ± 0.18

0.41 ± 0.12

67.4%*

0.0024

0.67 ± 0.1

0.63 ± 0.15

6%

0.8438

SERCA2a

2.67 ± 1.19

1.76 ± 0.37

52.2%

1.0000

2.43 ± 0.59

1.44 ± 0.33

68.7%*

0.0398

0.94 ± 0.23

0.99 ± 0.28

−5.8%

0.5625

RyR2

0.95 ± 0.28

0.94 ± 0.14

0.5%

1.0000

0.41 ± 0.11

0.5 ± 0.11

−17.3%

0.3804

0.26 ± 0.09

0.22 ± 0.04

17.6%

0.6875

Nav1.5

1.96 ± 0.35

1.97 ± 0.33

−0.8%

1.0000

1.16 ± 0.2

1.18 ± 0.28

−1.8%

0.8394

1.03 ± 0.13

1.21 ± 0.19

−15%

0.2188

hERG

0.19 ± 0.09

0.09 ± 0.03

97%

0.6250

0.17 ± 0.08

0.46 ± 0.24

−63.4%

0.1230

0.35 ± 0.15

0.24 ± 0.09

47.8%

0.1250