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Table 3 Distribution of key ion channel proteins in human myocardium and calculations regarding base-apex differences

From: Genomic upregulation of cardiac Cav1.2α and NCX1 by estrogen in women

Protein Group Base Apex % Difference P value
Cav1.2α Men 0.49 ± 0.1 0.47 ± 0.1 4.1% 1.0000
Adult women 0.57 ± 0.12 0.38 ± 0.09 48.8%* 0.0002
Postm. women 0.74 ± 0.25 0.59 ± 0.17 24.1% 0.5625
NCX1 Men 0.71 ± 0.07 0.64 ± 0.13 10.9% 0.6875
Adult women 0.68 ± 0.18 0.41 ± 0.12 67.4%* 0.0024
Postm. women 0.67 ± 0.1 0.63 ± 0.15 6% 0.8438
SERCA2a Men 2.67 ± 1.19 1.76 ± 0.37 52.2% 1.0000
Adult women 2.43 ± 0.59 1.44 ± 0.33 68.7%* 0.0398
Postm. women 0.94 ± 0.23 0.99 ± 0.28 −5.8% 0.5625
RyR2 Men 0.95 ± 0.28 0.94 ± 0.14 0.5% 1.0000
Adult women 0.41 ± 0.11 0.5 ± 0.11 −17.3% 0.3804
Postm. women 0.26 ± 0.09 0.22 ± 0.04 17.6% 0.6875
Nav1.5 Men 1.96 ± 0.35 1.97 ± 0.33 −0.8% 1.0000
Adult women 1.16 ± 0.2 1.18 ± 0.28 −1.8% 0.8394
Postm. women 1.03 ± 0.13 1.21 ± 0.19 −15% 0.2188
hERG Men 0.19 ± 0.09 0.09 ± 0.03 97% 0.6250
Adult women 0.17 ± 0.08 0.46 ± 0.24 −63.4% 0.1230
Postm. women 0.35 ± 0.15 0.24 ± 0.09 47.8% 0.1250
  1. Group mean ± SEM density values for each protein, normalized with GAPDH, and % base-apex differences in the human left ventricular epicardium. * P < 0.05, Wilcoxon matched-pairs signed rank test.