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Fig. 4 | Biology of Sex Differences

Fig. 4

From: Genomic upregulation of cardiac Cav1.2α and NCX1 by estrogen in women

Fig. 4

Effect of E2 incubation on ICa,L and INCX of female human iPS-CMs. a ICa,L current-voltage relationship from cardiac myocytes derived from hiPS cells was measured in cells cultured with 1 nM E2 (filled circles, n = 13) and compared to those cultured with vehicle (empty circles, n = 15). ICa,L was significantly increased by E2 incubation. (*P < 0.05). b INCX was measured as a function of voltage in female human iPS-CMs that were incubated with estradiol (filled circles, n = 5) and compared to iPS-CMs incubated with the vehicle (control) (empty circles, n = 5). There was a significant increase in INCX when incubated with E2. *P < 0.05

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