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Table 3 Renal parameters of anatomy, inflammation, and ER stress response

From: Sex differences in the development of vascular and renal lesions in mice with a simultaneous deficiency of Apoe and the integrin chain Itga8

  Genotype Sex Mean SEM Median Q1 Q3 IQR
Glomerular perimeter (μm) Apoe −/− Itga8 +/+ Male 202 2.47 202.5 197.5 208.9 11.4
Female 204 3.45 204.8 196.0 213.6 17.6
Apoe −/− Itga8 −/− Male 225 5.19 225.6 209.2 241.2 32.0
Female 234 6.51 234.0 220.0 247.3 27.3
Macrophage infiltration (no. of F4/80-pos. cells/view) Apoe −/− Itga8 +/+ Male 0.92 0.52 0.0 0.0 1.0 1.0
Female 7.17 4.21 3.5 3.5 16.5 13.0
Apoe −/− Itga8 −/− Male 53.9# 12.5 46.0 17.5 76.0 58.5
Female 53.0# 10.7 38.0 23.0 79.0 56.0
Spp1 mRNA expression (fold change) Apoe −/− Itga8 +/+ Male 0.38 0.03 0.39 0.32 0.45 0.13
Female 1.00* 0.07 1.04 0.87 1.12 0.25
Apoe −/− Itga8 −/− Male 0.49 0.05 0.47 0.37 0.64 0.27
Female 1.35* 0.20 1.11 1.02 1.71 0.69
Cxcl3 mRNA expression (fold change) Apoe −/− Itga8 +/+ Male 0.75 0.18 0.66 0.39 1.22 0.83
Female 1.00 0.29 0.91 0.42 1.63 1.21
Apoe −/− Itga8 −/− Male 2.61# 0.68 2.25 0.75 4.34 3.59
Female 1.25 0.41 0.71 0.64 1.91 1.27
Ccl2 mRNA expression (fold change) Apoe −/− Itga8 +/+ Male 0.89 0.19 0.92 0.37 1.38 1.01
Female 1.00 0.34 0.77 0.32 1.79 1.47
Apoe −/− Itga8 −/− Male 1.44 0.42 0.92 0.88 2.74 1.86
Female 0.93 0.25 0.76 0.50 0.95 0.45
Eif2ak3 mRNA expression (fold change) Apoe −/− Itga8 +/+ Male 0.80 0.07 0.84 0.60 0.96 0.36
Female 1.00 0.10 1.03 0.81 1.18 0.37
Apoe −/− Itga8 −/− Male 0.71 0.10 0.67 0.53 0.95 0.42
Female 0.86 0.06 0.85 0.79 1.02 0.23
Ddit3 mRNA expression (fold change) Apoe −/− Itga8 +/+ Male 0.89 0.13 0.87 0.57 1.23 0.66
Female 1.00 0.12 1.06 0.75 1.22 0.47
Apoe −/− Itga8 −/− Male 0.70 0.10 0.58 0.51 0.94 0.43
Female 0.88 0.08 0.78 0.74 0.99 0.25
Hspa5 mRNA expression (fold change) Apoe −/− Itga8 +/+ Male 0.92 0.13 0.88 0.63 1.25 0.62
Female 1.00 0.14 0.88 0.78 1.28 0.5
Apoe −/− Itga8 −/− Male 0.79 0.06 0.75 0.66 0.99 0.33
Female 0.81 0.08 0.79 0.66 0.98 0.32
Vegfa mRNA expression (fold change) Apoe −/− Itga8 +/+ Male 0.67 0.04 0.65 0.59 0.76 0.17
Female 1.00 0.05 1.02 0.90 1.11 0.21
Apoe −/− Itga8 −/− Male 0.68 0.05 0.66 0.59 0.79 0.2
Female 0.85 0.06 0.81 0.71 0.97 0.26
  1. # p < 0.05 vs Itga8 +/+ of the same sex
  2. *p < 0.05 vs male of the same genotype
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