Glomerular perimeter (μm)
|
Apoe
−/−
Itga8
+/+
|
Male
|
202
|
2.47
|
202.5
|
197.5
|
208.9
|
11.4
|
Female
|
204
|
3.45
|
204.8
|
196.0
|
213.6
|
17.6
|
Apoe
−/−
Itga8
−/−
|
Male
|
225
|
5.19
|
225.6
|
209.2
|
241.2
|
32.0
|
Female
|
234
|
6.51
|
234.0
|
220.0
|
247.3
|
27.3
|
Macrophage infiltration (no. of F4/80-pos. cells/view)
|
Apoe
−/−
Itga8
+/+
|
Male
|
0.92
|
0.52
|
0.0
|
0.0
|
1.0
|
1.0
|
Female
|
7.17
|
4.21
|
3.5
|
3.5
|
16.5
|
13.0
|
Apoe
−/−
Itga8
−/−
|
Male
|
53.9#
|
12.5
|
46.0
|
17.5
|
76.0
|
58.5
|
Female
|
53.0#
|
10.7
|
38.0
|
23.0
|
79.0
|
56.0
|
Spp1 mRNA expression (fold change)
|
Apoe
−/−
Itga8
+/+
|
Male
|
0.38
|
0.03
|
0.39
|
0.32
|
0.45
|
0.13
|
Female
|
1.00*
|
0.07
|
1.04
|
0.87
|
1.12
|
0.25
|
Apoe
−/−
Itga8
−/−
|
Male
|
0.49
|
0.05
|
0.47
|
0.37
|
0.64
|
0.27
|
Female
|
1.35*
|
0.20
|
1.11
|
1.02
|
1.71
|
0.69
|
Cxcl3 mRNA expression (fold change)
|
Apoe
−/−
Itga8
+/+
|
Male
|
0.75
|
0.18
|
0.66
|
0.39
|
1.22
|
0.83
|
Female
|
1.00
|
0.29
|
0.91
|
0.42
|
1.63
|
1.21
|
Apoe
−/−
Itga8
−/−
|
Male
|
2.61#
|
0.68
|
2.25
|
0.75
|
4.34
|
3.59
|
Female
|
1.25
|
0.41
|
0.71
|
0.64
|
1.91
|
1.27
|
Ccl2 mRNA expression (fold change)
|
Apoe
−/−
Itga8
+/+
|
Male
|
0.89
|
0.19
|
0.92
|
0.37
|
1.38
|
1.01
|
Female
|
1.00
|
0.34
|
0.77
|
0.32
|
1.79
|
1.47
|
Apoe
−/−
Itga8
−/−
|
Male
|
1.44
|
0.42
|
0.92
|
0.88
|
2.74
|
1.86
|
Female
|
0.93
|
0.25
|
0.76
|
0.50
|
0.95
|
0.45
|
Eif2ak3 mRNA expression (fold change)
|
Apoe
−/−
Itga8
+/+
|
Male
|
0.80
|
0.07
|
0.84
|
0.60
|
0.96
|
0.36
|
Female
|
1.00
|
0.10
|
1.03
|
0.81
|
1.18
|
0.37
|
Apoe
−/−
Itga8
−/−
|
Male
|
0.71
|
0.10
|
0.67
|
0.53
|
0.95
|
0.42
|
Female
|
0.86
|
0.06
|
0.85
|
0.79
|
1.02
|
0.23
|
Ddit3 mRNA expression (fold change)
|
Apoe
−/−
Itga8
+/+
|
Male
|
0.89
|
0.13
|
0.87
|
0.57
|
1.23
|
0.66
|
Female
|
1.00
|
0.12
|
1.06
|
0.75
|
1.22
|
0.47
|
Apoe
−/−
Itga8
−/−
|
Male
|
0.70
|
0.10
|
0.58
|
0.51
|
0.94
|
0.43
|
Female
|
0.88
|
0.08
|
0.78
|
0.74
|
0.99
|
0.25
|
Hspa5 mRNA expression (fold change)
|
Apoe
−/−
Itga8
+/+
|
Male
|
0.92
|
0.13
|
0.88
|
0.63
|
1.25
|
0.62
|
Female
|
1.00
|
0.14
|
0.88
|
0.78
|
1.28
|
0.5
|
Apoe
−/−
Itga8
−/−
|
Male
|
0.79
|
0.06
|
0.75
|
0.66
|
0.99
|
0.33
|
Female
|
0.81
|
0.08
|
0.79
|
0.66
|
0.98
|
0.32
|
Vegfa mRNA expression (fold change)
|
Apoe
−/−
Itga8
+/+
|
Male
|
0.67
|
0.04
|
0.65
|
0.59
|
0.76
|
0.17
|
Female
|
1.00
|
0.05
|
1.02
|
0.90
|
1.11
|
0.21
|
Apoe
−/−
Itga8
−/−
|
Male
|
0.68
|
0.05
|
0.66
|
0.59
|
0.79
|
0.2
|
Female
|
0.85
|
0.06
|
0.81
|
0.71
|
0.97
|
0.26
|