Biology of Sex Differences

Table 3 Renal parameters of anatomy, inflammation, and ER stress response

From: Sex differences in the development of vascular and renal lesions in mice with a simultaneous deficiency of Apoe and the integrin chain Itga8

	Genotype	Sex	Mean	SEM	Median	Q1	Q3	IQR
Glomerular perimeter (μm)	Apoe ^−/− Itga8 ^+/+	Male	202	2.47	202.5	197.5	208.9	11.4
	Apoe ^−/− Itga8 ^+/+	Female	204	3.45	204.8	196.0	213.6	17.6
	Apoe ^−/− Itga8 ^−/−	Male	225	5.19	225.6	209.2	241.2	32.0
	Apoe ^−/− Itga8 ^−/−	Female	234	6.51	234.0	220.0	247.3	27.3
Macrophage infiltration (no. of F4/80-pos. cells/view)	Apoe ^−/− Itga8 ^+/+	Male	0.92	0.52	0.0	0.0	1.0	1.0
	Apoe ^−/− Itga8 ^+/+	Female	7.17	4.21	3.5	3.5	16.5	13.0
	Apoe ^−/− Itga8 ^−/−	Male	53.9^#	12.5	46.0	17.5	76.0	58.5
	Apoe ^−/− Itga8 ^−/−	Female	53.0^#	10.7	38.0	23.0	79.0	56.0
Spp1 mRNA expression (fold change)	Apoe ^−/− Itga8 ^+/+	Male	0.38	0.03	0.39	0.32	0.45	0.13
	Apoe ^−/− Itga8 ^+/+	Female	1.00*	0.07	1.04	0.87	1.12	0.25
	Apoe ^−/− Itga8 ^−/−	Male	0.49	0.05	0.47	0.37	0.64	0.27
	Apoe ^−/− Itga8 ^−/−	Female	1.35*	0.20	1.11	1.02	1.71	0.69
Cxcl3 mRNA expression (fold change)	Apoe ^−/− Itga8 ^+/+	Male	0.75	0.18	0.66	0.39	1.22	0.83
	Apoe ^−/− Itga8 ^+/+	Female	1.00	0.29	0.91	0.42	1.63	1.21
	Apoe ^−/− Itga8 ^−/−	Male	2.61^#	0.68	2.25	0.75	4.34	3.59
	Apoe ^−/− Itga8 ^−/−	Female	1.25	0.41	0.71	0.64	1.91	1.27
Ccl2 mRNA expression (fold change)	Apoe ^−/− Itga8 ^+/+	Male	0.89	0.19	0.92	0.37	1.38	1.01
	Apoe ^−/− Itga8 ^+/+	Female	1.00	0.34	0.77	0.32	1.79	1.47
	Apoe ^−/− Itga8 ^−/−	Male	1.44	0.42	0.92	0.88	2.74	1.86
	Apoe ^−/− Itga8 ^−/−	Female	0.93	0.25	0.76	0.50	0.95	0.45
Eif2ak3 mRNA expression (fold change)	Apoe ^−/− Itga8 ^+/+	Male	0.80	0.07	0.84	0.60	0.96	0.36
	Apoe ^−/− Itga8 ^+/+	Female	1.00	0.10	1.03	0.81	1.18	0.37
	Apoe ^−/− Itga8 ^−/−	Male	0.71	0.10	0.67	0.53	0.95	0.42
	Apoe ^−/− Itga8 ^−/−	Female	0.86	0.06	0.85	0.79	1.02	0.23
Ddit3 mRNA expression (fold change)	Apoe ^−/− Itga8 ^+/+	Male	0.89	0.13	0.87	0.57	1.23	0.66
	Apoe ^−/− Itga8 ^+/+	Female	1.00	0.12	1.06	0.75	1.22	0.47
	Apoe ^−/− Itga8 ^−/−	Male	0.70	0.10	0.58	0.51	0.94	0.43
	Apoe ^−/− Itga8 ^−/−	Female	0.88	0.08	0.78	0.74	0.99	0.25
Hspa5 mRNA expression (fold change)	Apoe ^−/− Itga8 ^+/+	Male	0.92	0.13	0.88	0.63	1.25	0.62
	Apoe ^−/− Itga8 ^+/+	Female	1.00	0.14	0.88	0.78	1.28	0.5
	Apoe ^−/− Itga8 ^−/−	Male	0.79	0.06	0.75	0.66	0.99	0.33
	Apoe ^−/− Itga8 ^−/−	Female	0.81	0.08	0.79	0.66	0.98	0.32
Vegfa mRNA expression (fold change)	Apoe ^−/− Itga8 ^+/+	Male	0.67	0.04	0.65	0.59	0.76	0.17
	Apoe ^−/− Itga8 ^+/+	Female	1.00	0.05	1.02	0.90	1.11	0.21
	Apoe ^−/− Itga8 ^−/−	Male	0.68	0.05	0.66	0.59	0.79	0.2
	Apoe ^−/− Itga8 ^−/−	Female	0.85	0.06	0.81	0.71	0.97	0.26

^# p < 0.05 vs Itga8 ^+/+ of the same sex
*p < 0.05 vs male of the same genotype

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ISSN: 2042-6410

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