Aortic Itga8 mRNA expression (fold change)
|
Apoe
−/−
Itga8
+/+
|
Male
|
0.96
|
0.16
|
0.93
|
0.59
|
1.39
|
0.80
|
Female
|
1.00
|
0.26
|
1.05
|
0.35
|
1.62
|
1.27
|
Apoe
−/−
Itga8
−/−
|
Male
|
0.0002#
|
0.00
|
0.00
|
0.00
|
0.00
|
0.00
|
Female
|
0.05#
|
0.05
|
0.00
|
0.00
|
0.00
|
0.00
|
Plasma triglycerides (mg/dl)
|
Apoe
−/−
Itga8
+/+
|
Male
|
117
|
16
|
102
|
71.8
|
154
|
82.2
|
Female
|
78
|
7
|
77.8
|
56.7
|
102
|
45.3
|
Apoe
−/−
Itga8
−/−
|
Male
|
146
|
24
|
102
|
66.9
|
192
|
125.1
|
Female
|
111
|
25
|
81.3
|
58.5
|
114
|
55.5
|
Plasma total cholesterol (mg/dl)
|
Apoe
−/−
Itga8
+/+
|
Male
|
372
|
40
|
453
|
192
|
522
|
330
|
Female
|
406
|
22
|
425
|
345
|
476
|
131
|
Apoe
−/−
Itga8
−/−
|
Male
|
393
|
39
|
402
|
235
|
521
|
286
|
Female
|
263
|
28
|
270
|
155
|
363
|
208
|
Plasma HDL cholesterol [mg/dl]
|
Apoe
−/−
Itga8
+/+
|
Male
|
87
|
9
|
87
|
54
|
106
|
52
|
Female
|
96
|
6
|
96
|
83
|
106
|
23
|
Apoe
−/−
Itga8
−/−
|
Male
|
100
|
13
|
74
|
63
|
111
|
48
|
Female
|
95
|
7
|
87
|
74
|
101
|
27
|
Plasma LDL cholesterol (mg/dl)
|
Apoe
−/−
Itga8
+/+
|
Male
|
262
|
33
|
320
|
121
|
379
|
258
|
Female
|
295
|
18
|
311
|
251
|
340
|
89
|
Apoe
−/−
Itga8
−/−
|
Male
|
263
|
30
|
296
|
142
|
359
|
217
|
Female
|
163#*
|
23
|
159
|
67
|
241
|
174
|
Plasma testosterone (ng/dl)
|
Apoe
−/−
Itga8
+/+
|
Male
|
4
|
2
|
0.63
|
0.32
|
7.48
|
7.16
|
Female
|
0.2
|
0.0
|
0.15
|
0.03
|
0.24
|
9.21
|
Apoe
−/−
Itga8
−/−
|
Male
|
11
|
4
|
12.3
|
0.77
|
18.2
|
17.4
|
Female
|
0.2*
|
0.1
|
0.15
|
0.09
|
28.1
|
28.0
|
Plasma creatinine (μg/dl)
|
Apoe
−/−
Itga8
+/+
|
Male
|
52
|
9
|
50
|
20
|
80
|
60
|
Female
|
95
|
9
|
100
|
50
|
120
|
70
|
Apoe
−/−
Itga8
−/−
|
Male
|
97
|
8
|
100
|
70
|
130
|
60
|
Female
|
140
|
3
|
110
|
80
|
130
|
50
|
Plaques of aortic arch (%)
|
Apoe
−/−
Itga8
+/+
|
Male
|
17.7
|
2.34
|
17.1
|
11.7
|
20.6
|
8.9
|
Female
|
25.7
|
2.73
|
25.6
|
18.7
|
31.4
|
12.7
|
Apoe
−/−
Itga8
−/−
|
Male
|
26.6
|
2.27
|
25.8
|
20.3
|
34.3
|
14
|
Female
|
21.9
|
1.76
|
23.8
|
15.0
|
27.7
|
12.7
|
Calcification aorta (%)
|
Apoe
−/−
Itga8
+/+
|
Male
|
0.04
|
0.04
|
0.0
|
0.0
|
0.0
|
0
|
Female
|
2.84*
|
0.51
|
2.66
|
1.58
|
4.39
|
2,81
|
Apoe
−/−
Itga8
−/−
|
Male
|
0.85
|
0.37
|
0.0
|
0.0
|
1.98
|
1.98
|
Female
|
2.76
|
0.63
|
2.56
|
0.0
|
3.79
|
3.79
|