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Table 2 Cardiovascular and metabolic parameters

From: Sex differences in the development of vascular and renal lesions in mice with a simultaneous deficiency of Apoe and the integrin chain Itga8

  Genotype Sex Mean SEM Median Q1 Q3 IQR
Aortic Itga8 mRNA expression (fold change) Apoe −/− Itga8 +/+ Male 0.96 0.16 0.93 0.59 1.39 0.80
Female 1.00 0.26 1.05 0.35 1.62 1.27
Apoe −/− Itga8 −/− Male 0.0002# 0.00 0.00 0.00 0.00 0.00
Female 0.05# 0.05 0.00 0.00 0.00 0.00
Plasma triglycerides (mg/dl) Apoe −/− Itga8 +/+ Male 117 16 102 71.8 154 82.2
Female 78 7 77.8 56.7 102 45.3
Apoe −/− Itga8 −/− Male 146 24 102 66.9 192 125.1
Female 111 25 81.3 58.5 114 55.5
Plasma total cholesterol (mg/dl) Apoe −/− Itga8 +/+ Male 372 40 453 192 522 330
Female 406 22 425 345 476 131
Apoe −/− Itga8 −/− Male 393 39 402 235 521 286
Female 263 28 270 155 363 208
Plasma HDL cholesterol [mg/dl] Apoe −/− Itga8 +/+ Male 87 9 87 54 106 52
Female 96 6 96 83 106 23
Apoe −/− Itga8 −/− Male 100 13 74 63 111 48
Female 95 7 87 74 101 27
Plasma LDL cholesterol (mg/dl) Apoe −/− Itga8 +/+ Male 262 33 320 121 379 258
Female 295 18 311 251 340 89
Apoe −/− Itga8 −/− Male 263 30 296 142 359 217
Female 163#* 23 159 67 241 174
Plasma testosterone (ng/dl) Apoe −/− Itga8 +/+ Male 4 2 0.63 0.32 7.48 7.16
Female 0.2 0.0 0.15 0.03 0.24 9.21
Apoe −/− Itga8 −/− Male 11 4 12.3 0.77 18.2 17.4
Female 0.2* 0.1 0.15 0.09 28.1 28.0
Plasma creatinine (μg/dl) Apoe −/− Itga8 +/+ Male 52 9 50 20 80 60
Female 95 9 100 50 120 70
Apoe −/− Itga8 −/− Male 97 8 100 70 130 60
Female 140 3 110 80 130 50
Plaques of aortic arch (%) Apoe −/− Itga8 +/+ Male 17.7 2.34 17.1 11.7 20.6 8.9
Female 25.7 2.73 25.6 18.7 31.4 12.7
Apoe −/− Itga8 −/− Male 26.6 2.27 25.8 20.3 34.3 14
Female 21.9 1.76 23.8 15.0 27.7 12.7
Calcification aorta (%) Apoe −/− Itga8 +/+ Male 0.04 0.04 0.0 0.0 0.0 0
Female 2.84* 0.51 2.66 1.58 4.39 2,81
Apoe −/− Itga8 −/− Male 0.85 0.37 0.0 0.0 1.98 1.98
Female 2.76 0.63 2.56 0.0 3.79 3.79
  1. #p < 0.05 vs Itga8 +/+of the same sex
  2. *p < 0.05 vs male of the same genotype
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Biology of Sex Differences

ISSN: 2042-6410

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