Biology of Sex Differences

Table 2 Cardiovascular and metabolic parameters

From: Sex differences in the development of vascular and renal lesions in mice with a simultaneous deficiency of Apoe and the integrin chain Itga8

	Genotype	Sex	Mean	SEM	Median	Q1	Q3	IQR
Aortic Itga8 mRNA expression (fold change)	Apoe ^−/− Itga8 ^+/+	Male	0.96	0.16	0.93	0.59	1.39	0.80
	Apoe ^−/− Itga8 ^+/+	Female	1.00	0.26	1.05	0.35	1.62	1.27
	Apoe ^−/− Itga8 ^−/−	Male	0.0002^#	0.00	0.00	0.00	0.00	0.00
	Apoe ^−/− Itga8 ^−/−	Female	0.05^#	0.05	0.00	0.00	0.00	0.00
Plasma triglycerides (mg/dl)	Apoe ^−/− Itga8 ^+/+	Male	117	16	102	71.8	154	82.2
	Apoe ^−/− Itga8 ^+/+	Female	78	7	77.8	56.7	102	45.3
	Apoe ^−/− Itga8 ^−/−	Male	146	24	102	66.9	192	125.1
	Apoe ^−/− Itga8 ^−/−	Female	111	25	81.3	58.5	114	55.5
Plasma total cholesterol (mg/dl)	Apoe ^−/− Itga8 ^+/+	Male	372	40	453	192	522	330
	Apoe ^−/− Itga8 ^+/+	Female	406	22	425	345	476	131
	Apoe ^−/− Itga8 ^−/−	Male	393	39	402	235	521	286
	Apoe ^−/− Itga8 ^−/−	Female	263	28	270	155	363	208
Plasma HDL cholesterol [mg/dl]	Apoe ^−/− Itga8 ^+/+	Male	87	9	87	54	106	52
	Apoe ^−/− Itga8 ^+/+	Female	96	6	96	83	106	23
	Apoe ^−/− Itga8 ^−/−	Male	100	13	74	63	111	48
	Apoe ^−/− Itga8 ^−/−	Female	95	7	87	74	101	27
Plasma LDL cholesterol (mg/dl)	Apoe ^−/− Itga8 ^+/+	Male	262	33	320	121	379	258
	Apoe ^−/− Itga8 ^+/+	Female	295	18	311	251	340	89
	Apoe ^−/− Itga8 ^−/−	Male	263	30	296	142	359	217
	Apoe ^−/− Itga8 ^−/−	Female	163^#*	23	159	67	241	174
Plasma testosterone (ng/dl)	Apoe ^−/− Itga8 ^+/+	Male	4	2	0.63	0.32	7.48	7.16
	Apoe ^−/− Itga8 ^+/+	Female	0.2	0.0	0.15	0.03	0.24	9.21
	Apoe ^−/− Itga8 ^−/−	Male	11	4	12.3	0.77	18.2	17.4
	Apoe ^−/− Itga8 ^−/−	Female	0.2*	0.1	0.15	0.09	28.1	28.0
Plasma creatinine (μg/dl)	Apoe ^−/− Itga8 ^+/+	Male	52	9	50	20	80	60
	Apoe ^−/− Itga8 ^+/+	Female	95	9	100	50	120	70
	Apoe ^−/− Itga8 ^−/−	Male	97	8	100	70	130	60
	Apoe ^−/− Itga8 ^−/−	Female	140	3	110	80	130	50
Plaques of aortic arch (%)	Apoe ^−/− Itga8 ^+/+	Male	17.7	2.34	17.1	11.7	20.6	8.9
	Apoe ^−/− Itga8 ^+/+	Female	25.7	2.73	25.6	18.7	31.4	12.7
	Apoe ^−/− Itga8 ^−/−	Male	26.6	2.27	25.8	20.3	34.3	14
	Apoe ^−/− Itga8 ^−/−	Female	21.9	1.76	23.8	15.0	27.7	12.7
Calcification aorta (%)	Apoe ^−/− Itga8 ^+/+	Male	0.04	0.04	0.0	0.0	0.0	0
	Apoe ^−/− Itga8 ^+/+	Female	2.84*	0.51	2.66	1.58	4.39	2,81
	Apoe ^−/− Itga8 ^−/−	Male	0.85	0.37	0.0	0.0	1.98	1.98
	Apoe ^−/− Itga8 ^−/−	Female	2.76	0.63	2.56	0.0	3.79	3.79

#p < 0.05 vs Itga8 ^+/+of the same sex
*p < 0.05 vs male of the same genotype

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ISSN: 2042-6410

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