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Table 4 Replication and meta-analysis of manifestations with different frequencies among female and male patients with pSS

From: Difference in clinical presentation between women and men in incident primary Sjögren’s syndrome

  Ramírez Sepúlveda et al. Baldini et al. Meta-analysis
Women (n = 186) % (frequency) Men (n = 13) % (frequency) p value Women (n = 368) % (frequency) Men (n = 9) % (frequency) p value p value
Age at diagnosis 56 ± 14 46 ± 12 0.01 51 ± 15 53 ± 13 0.86 0.07
Positive MSG biopsya 95% (149/157) 83% (10/12) 0.10 93% (293/315) 100% (8/8) 0.43 0.30
Presence of EGMb 25% (47/185) 46% (6/13) 0.10 56% (205/368) 100% (9/9) 0.006 0.005
No. of EGMc 0.30 ± 0.57 0.85 ± 1.21 0.05 1.11 ± 1.39 2.89 ± 1.62 0.0003 0.002
No. of EGM in EGM + c 1.19 ± 0.45 1.83 ± 1.17 0.04 1.89 ± 1.16 2.67 ± 1.41 0.06 0.04
Interstitial lung disease 0% (0/183) 15% (2/13) 0.004 9% (32/368) 22% (2/9) 0.19 0.002
Alveolitis 0% (0/184) 8% (1/13) 0.07 2% (6/368) 0% (0/9) 1.00 0.01
Cutaneous vasculitis 2% (4/182) 23% (3/13) 0.007 10% (38/368) 11% (1/9) 1.00 0.03
Lymphadenopathy 2% (3/184) 8% (1/13) 0.24 37% (138/367) 89% (8/9) 0.003 0.004
Recurrent fever 7% (12/184) 15% (2/13) 0.23 18% (66/368) 67% (6/9) 0.002 0.0008
  1. MSG minor salivary gland biopsy
  2. aFocus score ≥1
  3. bExtraglandular manifestations evaluated to estimate the EULAR Sjögren’s syndrome disease activity index (ESSDAI)
  4. c(mean ± SD)
  5. Bold values indicate statistically significant findings (p < 0.05)