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Table 4 Replication and meta-analysis of manifestations with different frequencies among female and male patients with pSS

From: Difference in clinical presentation between women and men in incident primary Sjögren’s syndrome

 

Ramírez Sepúlveda et al.

Baldini et al.

Meta-analysis

Women (n = 186)

% (frequency)

Men (n = 13)

% (frequency)

p value

Women (n = 368)

% (frequency)

Men (n = 9)

% (frequency)

p value

p value

Age at diagnosis

56 ± 14

46 ± 12

0.01

51 ± 15

53 ± 13

0.86

0.07

Positive MSG biopsya

95% (149/157)

83% (10/12)

0.10

93% (293/315)

100% (8/8)

0.43

0.30

Presence of EGMb

25% (47/185)

46% (6/13)

0.10

56% (205/368)

100% (9/9)

0.006

0.005

No. of EGMc

0.30 ± 0.57

0.85 ± 1.21

0.05

1.11 ± 1.39

2.89 ± 1.62

0.0003

0.002

No. of EGM in EGM + c

1.19 ± 0.45

1.83 ± 1.17

0.04

1.89 ± 1.16

2.67 ± 1.41

0.06

0.04

Interstitial lung disease

0% (0/183)

15% (2/13)

0.004

9% (32/368)

22% (2/9)

0.19

0.002

Alveolitis

0% (0/184)

8% (1/13)

0.07

2% (6/368)

0% (0/9)

1.00

0.01

Cutaneous vasculitis

2% (4/182)

23% (3/13)

0.007

10% (38/368)

11% (1/9)

1.00

0.03

Lymphadenopathy

2% (3/184)

8% (1/13)

0.24

37% (138/367)

89% (8/9)

0.003

0.004

Recurrent fever

7% (12/184)

15% (2/13)

0.23

18% (66/368)

67% (6/9)

0.002

0.0008

  1. MSG minor salivary gland biopsy
  2. aFocus score ≥1
  3. bExtraglandular manifestations evaluated to estimate the EULAR Sjögren’s syndrome disease activity index (ESSDAI)
  4. c(mean ± SD)
  5. Bold values indicate statistically significant findings (p < 0.05)
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Biology of Sex Differences

ISSN: 2042-6410

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