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Table 5 Sex differences in ACE, ACE2, NEP, APN, and APA serum activities in younger (<55 years) and older (≥ 55 years) participants

From: Sex differences in the aging pattern of renin–angiotensin system serum peptidases

   WOMEN MEN Mann–Whitney U
  Median IQR N Median IQR N Z P value
< 55 years ACE 820.3 249.77 28 841.4 281.02 31 −0.728 0.467
ACE2 61.71 16.69 28 59.75 23.57 31 −0.032 0.975
NEP 15474 1187.55 28 16203 2030.32 31 −2.017 0.044
APN 9931 5046.74 28 11517 6916.75 31 −1.653 0.098
APA 4304 1225.79 28 4281 1633.4 31 −0.121 0.903
> 55 years ACE 815.9 272.13 30 744.4 201.43 29 −2.292 0.022
ACE2 71.11 16.22 30 70,05 30.92 29 −0.378 0.706
NEP 15703 1812.15 30 15344 1668.93 29 −0.562 0.574
APN 10238 6688.67 30 9973 4001.23 29 −0.577 0.564
APA 4361 1240.15 30 3820 623.97 29 −2.763 0.006
  1. Note: ACE angiotensin-converting enzyme, ACE2 angiotensin-converting enzyme-2, NEP neutral endopeptidase, APN aminopeptidase N, APA aminopeptidase A