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Table 2 Sex differences in liver histopathology

From: Sex and age differences in the expression of liver microRNAs during the life span of F344 rats

Lesion

 

52 weeks of age

78 weeks of age

104 weeks of age

 

Female

Male

Female

Male

Female

Male

Sex bias

Incidence

Avg. severity scoreb

Incidence

Avg. severity scoreb

Incidence

Avg. severity scoreb

Incidence

Avg. severity scoreb

Incidence

Avg. severity scoreb

Incidence

Avg. severity scoreb

Basophilic focusa

Female

0/10

–

0/10

–

3/8

–

0/8

–

12/16

–

0/14

–

Hyperplasia, bile duct

Male

0/10

–

8/10

1.6

2/8

1.5

7/8

1.4

2/16

2

10/14

1.9

Vacuolization, cytoplasm, hepatocyte

Male

0/10

–

5/10

1.4

0/8

–

2/8

2.5

0/16

–

1/14

4

  1. aBasophilic loci scored as present or absent, without a severity score [53]
  2. bAverage among those animals showing the lesion