Table 2 Sex differences in liver histopathology
From: Sex and age differences in the expression of liver microRNAs during the life span of F344 rats
| Lesion | 52 weeks of age | 78 weeks of age | 104 weeks of age | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Female | Male | Female | Male | Female | Male | ||||||||
| Sex bias | Incidence | Avg. severity scoreb | Incidence | Avg. severity scoreb | Incidence | Avg. severity scoreb | Incidence | Avg. severity scoreb | Incidence | Avg. severity scoreb | Incidence | Avg. severity scoreb | |
| Basophilic focusa | Female | 0/10 | – | 0/10 | – | 3/8 | – | 0/8 | – | 12/16 | – | 0/14 | – |
| Hyperplasia, bile duct | Male | 0/10 | – | 8/10 | 1.6 | 2/8 | 1.5 | 7/8 | 1.4 | 2/16 | 2 | 10/14 | 1.9 |
| Vacuolization, cytoplasm, hepatocyte | Male | 0/10 | – | 5/10 | 1.4 | 0/8 | – | 2/8 | 2.5 | 0/16 | – | 1/14 | 4 |