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Table 1 mRNA targets and pathways/functions associated with differentially expressed miRNAs

From: Sex and age differences in the expression of liver microRNAs during the life span of F344 rats

miRNA class miRNAs in classa # of miRNAs in class Predicted mRNA targetsb # of mRNA targets Potentially affected pathways/functionsc
2-week-specific expression miR-127, miR-127*, miR-136, miR-136*, miR-154, miR-154*, miR-299, miR-300-3p, miR-322*, miR-329, miR-337, miR-337*, miR-341, miR-3563-3p, miR-369-5p, miR-376a, miR-376b-3p, miR-376b-5p, miR-376c, miR-379, miR-381, miR-382, miR-409-5p, miR-410, miR-411, miR-411*, miR-431, miR-434, miR-434*, miR-455, miR-483, miR-487b, miR-495, miR-541, miR-542-3p, miR-542-5p, miR-582, miR-675* 38 BCL6, CAPN8, CNTN4, ONECUT1, PRDM1, RTL1, SEPT3, TAGLN, VIM, XBP1 10 Molecular functions: Cellular development Cellular growth and maintenance Cellular growth and proliferation Cell morphology Cell to cell signaling Physiological systems: Hematological system
Sex difference in adults miR-100, miR-107, miR-125b-5p, miR-139-3p, miR-144, miR-151, miR-152, miR-191*, miR-200b, miR-203, miR-21, miR-221, miR-27b, miR-290, miR-29b, miR-326, miR-339-3p, miR-340-3p, miR-34b, miR-374, miR-425, miR-466b-2*, miR-505*, miR-532-3p, miR-598-3p, miR-652, miR-802, miR-96, miR-99a, miR-99a* 30 Acvr2a, Adamts1, Adcy6, Adora1, Adora2b, Akap6, Apaf1, Aqp5, Arc, Axin2, B3galt4, Bace1, Bak1, Bcl2, Bcl2l11, Bmf, Bmpr2, Bnip3l, Btg2, Capn8, Casp6, Casp7, Cbln2, Cbx7, Ccnd1, Ccne1, Cd276, Cdc25a, Cdca4, Cdk6, Cdkn1a, Cdkn1b, Cdkn2a, Cebpg, Celsr2, Cntn4, Col1a1, Col1a2, Col3a1, Col4a1, Col5a3, Crkl, Cyp1a1, Cyp1b1, Ddit4, Dicer1, Dio3, Dll1, Dnmt1, Dnmt3a, Dnmt3b, Dusp2, E2f5, Elmo2, Erbb2, Erbb3, Errfi1, Esr1, Fadd, Fam3c, Fbn1, Fgf16, Fgfr3, Fos, Golph3, Gpr160, H3f3b, Hdac4, Hipk3, Htr1b, Icam1, Icos, Id1, Id2, Id3, Igf1r, Igfbp3, Il1rn, Irs1, Jag1, Kcnj16, Kit, Klf15, Lamc1, Madd, Map2k1, Mapk1, Mcl1, Met, Mgst1, Mitf, Mmp13, Mmp9, Myc, Myrip, Nfib, Notch1, Notch2, Nr1i2, Nr4a1, Odc1, Pdcd4, Peli1, Pex7, Phb, Pigr, Pik3r1, Plag1, Plk1, Pparg, Ppp2r2a, Pten, Ptprd, Rere, Runx1, Rxra, Ryk, Serpinb5, Sgpl1, Slc16a10, Smad3, Smad4, Smad5, Smo, Socs3, Sod2, Sox5, Sp1, Sparc, Spry2, Srm, Ssr3, St14, St18, Stx1a, Syt4, Tagln, Tdg, Tgfb3, Timp3, Tp53, Tpm1, Tspan8, Ube2i, Ugt2b, Vegfa, Vsnl1, Wisp2, Yy1 149 Molecular functions: Cellular growth and proliferation Cell death and survival Cellular development Gene expression Cell cycle Toxicological functions: Liver necrosis Liver proliferation Liver fibrosis Hepatocellular carcinoma Liver hyperplasia
Sex difference in old miR-125b-5p, miR-152, miR-183, miR-29b, miR-31, miR-31*, miR-340-5p, miR-374, miR-494, miR-92a, miR-96, miR-99a, miR-99a* 13 Acvr2a, Adamts1, Adcy6, Aqp5, B3galt4, Bace1, Bak1, Bcl2l11, Bmf, Bmpr2, Btrc, Casp6, Casp7, Casr, Cbln2, Cbx7, Cd276, Cdc25a, Cdk6, Cdkn2a, Cebpg, Celsr2, Col1a1, Col1a2, Col3a1, Col4a1, Col5a3, Cyp1a1, Dicer1, Dio3, Dnmt1, Dnmt3a, Dnmt3b, Dusp2, Erbb2, Erbb3, Fbn1, Fgf16, Fgfr3, Gpr160, H3f3b, Hdac4, Hif1a, Hipk3, Hmox1, Htr1b, Id1, Id2, Id3, Igf1r, Igfbp3, Il1rn, Irs1, Lamc1, Map2k4, Mcl1, Mitf, Myrip, Nr1i2, Pdgfb, Pigr, Pik3r1, Plk1, Ppp2r2a, Pten, Ryk, Scn3a, Sgpl1, Smo, Sp1, Sparc, St18, Tdg, Tgfb3, Tp53, Tpm1, Tspan8, Ube2i, Ugt2b, Vsnl1, Yy1 81 Molecular functions: Cellular death and survival Cellular development Cellular growth and proliferation Gene expression Cell cycle Toxicological functions: Liver necrosis
Difference between adults and old (male) miR-125b-5p, miR-146b, miR-200b, miR-203, miR-221, miR-29a, miR-29b, miR-29c, miR-324-5p, miR-34a, miR-375, miR-455*, miR-466b-2*, miR-598-3p, miR-802, miR-99a, miR-99a* 17 Acvr2a, Adamts1, Adipor2, Axin2, B3galt4, Bace1, Bak1, Bcl2, Bcl2l11, Blmh, Bmf, Bnip3l, Brca1, C1qbp, Casp6, Casp7, Cbln2, Cbx7, Ccna2, Ccnd1, Cd276, Cdc25a, Cdk6, Cdkn1b, Cdkn2a, Cebpg, Cfh, Col1a1, Col1a2, Col3a1, Col4a1, Col5a3, Cxcr4, Cyp1a1, Ddit4, Dicer1, Dio3, Dll1, Dnmt3a, Dnmt3b, Dusp2, E2f5, Elmo2, Erbb2, Erbb3, Errfi1, Esr1, Fadd, Fbn1, Fgf16, Fgfr3, Fos, Gpr160, H3f3b, Hdac4, Icam1, Id1, Id2, Id3, Igf1r, Igfbp3, Il1rn, Irak2, Jag1, Jak2, Kif22, Kit, Lamc1, Ltb, Map2k1, Mcl1, Met, Mettl7a, Mmp16, Mtpn, Myc, Notch1, Notch2, Pa2g4, Pigr, Pik3r1, Plekha4, Plk1, Ppp2r2a, Ptprd, Rere, Sdcbp2, Sgpl1, Smo, Socs3, Sod2, Sp1, Sparc, St18, Stat1, Tagln, Tdg, Tgfb3, Timeless, Tp53, Tpm1, Tspan8, Ube2i, Ugt2b, Usp1, Vegfa, Wisp2, Ywhaz, Yy1 109 Molecular functions: Cellular death and survival Cellular growth and proliferation Gene expression Cell cycle Cellular development Toxicological functions: Liver necrosis/cell death Hepatocellular carcinoma Liver hyperplasia Liver proliferation Liver fibrosis
Difference between adults and old (female) miR-1, miR-133b, miR-182, miR-183, miR-18a, miR-206, miR-29a, miR-29b, miR-29c, miR-34a, miR-375, miR-466b, miR-466b-2*, miR-96 14 Acvr2a, Adar, Adcy6, Adipor2, Aqp5, Arcn1, Arf3, Arf4, Arhgap29, Atp6v1b2, Axin2, Axl, Bace1, Bcl2, Bcl2l11, Bdnf, Blcap, Btrc, C1qbp, Calm3, Cand1, Cap1, Ccnd1, Cd276, Cdc42, Cdk6, Cdk9, Celsr2, Clcn3, Cnn3, Col1a1, Col1a2, Col3a1, Col4a1, Col5a3, Ctgf, Ddx5, Dll1, Dnmt3a, Dnmt3b, Dusp2, E2f5, Esr1, Fbln2, Fbn1, Fstl1, Gja1, H3f3b, Hand2, Hdac4, Htr1b, Igf1, Igf1r, Irs1, Jag1, Jak2, Kcnj2, Klf15, Lamc1, Lasp1, Lin7c, Lztfl1, Map2k1, Mcl1, Met, Mitf, Mmd, Mtpn, Myc, Myrip, Nfatc4, Notch1, Notch2, Notch3, Oat, Pdcd4, Pik3r1, Pim1, Pitx3, Pola1, Pom121, Rabl2a, RGD1359334, Rhoa, Rnf138, Runx2, Ryk, Sdc4, Serpinb5, Sh2d4a, Slc25a30, Sp1, Sparc, Srxn1, Tac1, Tagln, Tagln2, Tdg, Tdp1, Tgfb3, Thbs1, Timp3, Tns4, Tpm1, Trappc3, Trim2, Tspan4, Uhmk1, Usp1, Utrn, Vegfa, Wisp2, Xpo6, Ywhaz, Yy1 115 Molecular functions: Cellular death and survival Cellular growth and proliferation Gene expression Cellular development Cell cycle Toxicological functions: Liver necrosis/cell death Liver proliferation
  1. amiRNAs in italics have known mRNA targets in the IPA database
  2. bDerived from rat-specific miRNA-mRNA associations except for the 2-week-specific miRNA class, which included both rat- and human-specific miRNA-mRNA associations in IPA
  3. cFrom IPA pathway/function analysis with criteria of at least three mRNAs per pathway/function and a Fisher’s exact test p value < 10−3