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Table 2 q values for the effect of DOX, sex, and the interaction between sex and DOX in regulating CYP genes expression based on a 2-way ANOVA analysis and a 5% false discovery rate

From: Sex-dependent alteration of cardiac cytochrome P450 gene expression by doxorubicin in C57Bl/6 mice

 

1 day post-DOX

6 days post-DOX

DOX effect

Sex effect

Interaction effect

DOX effect

Sex effect

Interaction effect

Cyp1a1

0.0001*

0.3346

0.3865

0.4935

0.0064*

0.1977

Cyp1b1

<0.0001*

<0.0001*

0.0200*

0.0013*

0.0064*

0.0831

Cyp2c29

0.0012*

0.0006*

0.0200*

0.86

0.0433*

1.0000

Cyp2c44

0.0013*

0.051

0.1048

0.08

0.0064*

0.9700

Cyp2e1

<0.0001*

0.0164*

0.0364*

0.08

0.5371

1.0000

Cyp2j9

<0.0001*

0.2994

0.0567

0.2812

0.0727

1.0000

Cyp4a10

<0.0001*

0.0009*

0.3627

0.0943

0.1776

1.0000

  1. Specific post-hoc testing results can be found on the relevant figures
  2. *q < 0.05 denotes discoveries
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Biology of Sex Differences

ISSN: 2042-6410

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