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Table 1 Heart pathology scores based on evaluation of hematoxylin and eosin (HE) and trichome stained sections

From: Sex-dependent alteration of cardiac cytochrome P450 gene expression by doxorubicin in C57Bl/6 mice

Pathology Interstitial cellularity Vacuolization Fibrosis Cumulative
Degree 0 1 2 3 4 0 1 2 3 4 0 1 2 3 4 Mean Median 95% CI
Male Control 6 0 0 0 0 6 0 0 0 0 6 0 0 0 0 0 0 0
DOX 0 2 2 0 0 0 1 2 1 0 1 3 0 0 0 4.25 4.5* 3–5
Female Control 2 3 0 0 0 5 0 0 0 0 5 0 0 0 0 0.6 1 0–1
DOX 0 4 1 0 0 3 2 0 0 0 3 2 0 0 0 2 2# 1–3
  1. *p < 0.05 compared to saline-treated mice of the same sex; # p < 0.05 compared to male DOX-treated mice