Table 1 Heart pathology scores based on evaluation of hematoxylin and eosin (HE) and trichome stained sections
From: Sex-dependent alteration of cardiac cytochrome P450 gene expression by doxorubicin in C57Bl/6 mice
Pathology | Interstitial cellularity | Vacuolization | Fibrosis | Cumulative | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Degree | 0 | 1 | 2 | 3 | 4 | 0 | 1 | 2 | 3 | 4 | 0 | 1 | 2 | 3 | 4 | Mean | Median | 95% CI | |
Male | Control | 6 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
DOX | 0 | 2 | 2 | 0 | 0 | 0 | 1 | 2 | 1 | 0 | 1 | 3 | 0 | 0 | 0 | 4.25 | 4.5* | 3–5 | |
Female | Control | 2 | 3 | 0 | 0 | 0 | 5 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 0 | 0 | 0.6 | 1 | 0–1 |
DOX | 0 | 4 | 1 | 0 | 0 | 3 | 2 | 0 | 0 | 0 | 3 | 2 | 0 | 0 | 0 | 2 | 2# | 1–3 | |