Fig. 7
From: Sex-dependent alteration of cardiac cytochrome P450 gene expression by doxorubicin in C57Bl/6 mice
Effect of DOX exposure on Cyp2e1 and Cyp2j9 gene expression. Total RNA was isolated from the hearts of male or female C57Bl/6 mice collected 24 h or 6 days after the administration of 20 mg/kg DOX or saline. Gene expression of a Cyp2e1 or b Cyp2j9 was determined by real-time PCR. Results of all groups were normalized to beta-actin levels and are expressed relative to male control of the same time point. Values are expressed as mean ± SEM. *p < 0.05, compared to control mice of the same sex; #p < 0.05, compared to male DOX-treated mice by Tukey’s post-hoc analysis. Main effects are not represented statistically on the figures, and the reader can refer to Table 2 for the main effects statistics