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Fig. 1 | Biology of Sex Differences

Fig. 1

From: Sex-dependent alteration of cardiac cytochrome P450 gene expression by doxorubicin in C57Bl/6 mice

Fig. 1

Adult male and female C57Bl/6 mice were administered a single intraperitoneal injection of 20 mg/kg DOX or equivalent volume of sterile saline. a Body weight and b heart weight to tibial length were measured 24 h (n = 8 per group) or 6 days (n = 4–6 per group) after the administration of DOX or saline in male or female mice. c Stroke volume was assessed by trans-thoracic echocardiography 5 days after DOX or saline administration in male or female mice (n = 5–6 per group). Values are expressed as mean ± SEM. *p < 0.05, compared to saline-treated mice of the same sex by Tukey’s post-hoc analysis

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