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Table 3 Summary of alterations in CRF-OE mice and WT littermates influenced by CRF-OE and fasting with sex difference

From: Corticotropin-releasing factor overexpression in mice abrogates sex differences in body weight, visceral fat, and food intake response to a fast and alters levels of feeding regulatory hormones

  Basal Fasting
WT CRF-OE WT CRF-OE
Body weight F < M F↑ ↓ F > M ↓ < WT
Fat F < M ↓ F < M (−)
Adrenal glands F > M ↑ F > M (−) (−)
Fasting blood glucose    (−) ↑ F > M
Refeeding    ↑ F > M
Plasma Corticosterone (−) (−)
Leptin F < M M↓ (−)
Insulin (−)
Acyl ghrelin (−) M↑ (−)
PYY (−) (−) M↓ M↓
Hypothalamus NPY (−) F↑ (−)
POMC (−) (−) M↓ M↓, F↑
LepR (−) (-) (-)