Gene-specific sex effects on eosinophil infiltration in leishmaniasis

Table 2 Main effect of loci that control eosinophil numbers in the inguinal lymph nodes of L. major-infected F₂ hybrids between CcS-9 and BALB/c

Locus	Group	Marker	Genotype									P value	Corr. P value	% of expl. var.
Locus	Group	Marker	CC			CS			SS			P value	Corr. P value	% of expl. var.
Lmr14	Both sexes	D2Mit283	2.62	1.229	±0.003	3.62	1.234	±0.002	2.67	1.229	±0.002	NS	NS	NA
				(n = 57)			(n = 111)			(n = 74)
	Females		1.24	1.217	±0.003	1.45	1.220	±0.002	1.62	1.221	±0.003	NS	NS	NA
				(n = 35)			(n = 61)			(n = 32)
	Males both crosses		5.15	1.239	±0.005	8.94	1.247	±0.003	4.02	1.236	±0.004	5.5 × 10⁻²	NS	NA
				(n = 22)			(n = 50)			(n = 41)
	Males (BALB/c × CcS-9)F₂		3.37	1.233	±0.006	9.09	1.242	±0.004	3.78	1.235	±0.005	NS	NS	NA
				(n = 15)			(n = 32)			(n = 27)
	Males (CcS-9 × BALB/c)F₂		13.63	1.253	±0.005	18.34	1.257	±0.004	4.51	1.237	±0.005	1.08 × 10⁻⁴	8.11 × 10 ⁻³	36.22
				(n = 7)			(n = 18)			(n = 14)
Lmr25	Both sexes	D5Mit143	2.07	1.225	±0.003	4.33	1.237	±0.002	1.96	1.225	±0.003	9.53 × 10⁻⁴	4.36 × 10 ⁻²	5.02
				(n = 66)			(n = 107)			(n = 67)
	Females		1.09	1.215	±0.003	2.04	1.225	±0.002	1.20	1.216	±0.003	6.3 × 10⁻³	NS	NA
				(n = 37)			(n = 56)			(n = 36)
	Males		5.71	1.241	±0.004	7.40	1.244	±0.003	4.41	1.237	±0.004	NS	NS	NA
				(n = 31)			(n = 51)			(n = 31)

Mean and SE values were obtained by analysis of variance. In order to obtain normal distribution required for analysis of variance, the value of eosinophil numbers in the inguinal lymph nodes was transformed by using the 0.1th power of natural logarithm of the (observed value ×1000). The numbers in bold give the average non-transformed values. C and S indicate the presence of BALB/c and STS allele, respectively
n number of mice

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