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Fig. 3 | Biology of Sex Differences

Fig. 3

From: Gene-specific sex effects on eosinophil infiltration in leishmaniasis

Fig. 3

Loci controlling eosinophil numbers in CcS-9. The regions of STS and BALB/c origins are represented as dark and white, respectively; the boundary regions of undetermined origin are shaded. C and S indicate the presence of BALB/c and STS allele, respectively. Only the markers and SNPs defining the boundaries the STS-derived segment and the markers that were tested for linkage are shown. The markers that exhibit significant P values (genome-wide corrected) are shown in bold. Lmr loci on chromosomes 2 and 11 detected in a cross between CcS-9 and BALB/c overlap with loci Lmr14 [9193] and Lmr15 [91, 93] detected in cross of CcS-16 with BALB/c, and were therefore given the same name. Abbreviations show genes that have been reported to be involved in eosinophil functions: Bcl2l1 (BCL2-like 1) [78], Ccl11 (chemokine (C-C motif) ligand 11) [79] Ccl3 (chemokine (C-C motif) ligand 3) [79], Ccl5 (chemokine (C-C motif) ligand 5) [79], Ccl7 (chemokine (C-C motif) ligand 7) [79], Ccl8 (chemokine (C-C motif) ligand 8) [80], Ccrl2 (chemokine (C-C motif) receptor-like 2) [81], Cish (cytokine inducible SH2-containing protein) [82], Gnai2 (guanine nucleotide binding protein (G protein), alpha inhibiting 2) [83], Hck (hemopoietic cell kinase) [84], Hmgb1 (high mobility group box 1) [85], Il13 (interleukin 13) [86], Il3 (interleukin 3) [87], Il4 (interleukin 4) [88], Il5 (interleukin 5) [89], and Nlrp3 (NLR family, pyrin domain containing 3) [90]. However, the effects of eosinophil controlling loci might be caused by genes that are at the present not considered as candidates

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