A primer on the use of mouse models for identifying direct sex chromosome effects that cause sex differences in non-gonadal tissues

Table 3 Progeny of Cross A: XX x XY*

Genotypes^a	Gonads	NPX^b	NPY	Sry	PAR [−Sts]^b	Sts	X^m	X^p	Xⁱ
X^mO (rare)^c	F	1	0	0	1	1	1	0	0
X^mY*^X	F	1+	0	0	2	2	1	0	0
X^mX^p	F	2	0	0	2	2	1	1	1
X^mY*	M	1+	1	1	3	1	1	0	0
X^mX^pY*	M	2	1	1	3	1	1	1	1

^aParental sources of the X chromosomes (X^m: maternal; X^p: paternal) are included in Tables 4, 5, and 6, since these crosses are also used to identify effects of parental X imprinting
^bFigure 3 illustrates the structures of the Y*, X^Y*, and Y*^X chromosomes and the gene content of Y*^X that includes the minute + subsegment of NPX that is also present in Y*. Note that the Y* and X^Y* PARs have a duplication of PAR regions A and B but lack PAR region C that encompasses the Sts locus
^cX^mO are rare (~1% [75])

ISSN: 2042-6410