Table 2 Expression of genes in female BMMCs relative to male BMMCs, involving granule biogenesis and maturation
Gene name | Gene symbol | Comments | Statistics | |
|---|---|---|---|---|
Log2 fold change | q value | |||
Spermidine synthetase | Srm | Synthesizes polyamines important in granule biogenesis and homeostasis, including storage of histamine and proteases (Garcia-Faroldi, 2010 [47]) | 3.68 | 0.00016 |
Ornithine decarboxylase 1 | Odc1 | Synthesizes polyamines important in granule biogenesis and homeostasis, including storage of histamine and proteases (Garcia-Faroldi, 2010 [47]) | 2.52 | 0.00016 |
Spermine synthetase | Sms | Synthesizes polyamines important in granule biogenesis and homesostasis, including storage of histamine and proteases (Garcia-Faroldi, 2010 [47]) | 0.54 | 0.0045 |
Basic helix-loop-helix family, member A15 | Bhlha15 | Important transcription factor in forming mature secretory granules in a variety of specialized secretory cells (Tian 2010 [72]) | 3.42 | 0.00016 |
Rab5c, member of Ras oncogene family | Rab5c | Key regulator of mast cell granule fusion during biogenesis (Azouz 2014 [48]) | 0.62 | 0.00032 |
Mannose-6-phosphate receptor | M6pr | Transports glycosylated proteins, such as lysosomal hydrolases and TNF, into vesicles (Coutinho 2012 [50], Olszewski 2006 [73]) | 0.43 | 0.00016 |
Adaptor protein 1A complex | Ap1m1 | Protein necessary for the sorting of proteins into vesicles and secretory granule maturation (Bonnemaison 2014 [49]) | 0.36 | 0.0033 |
ATPase, H+ transporting, lysosomal 16 kDa, V0 subunit c | Atp6v0c | Component of a vacuolar type H+ ATPase that acidifies granule lumen for condensation of granule contents (Borges 2011) | 0.69 | 0.00016 |
ATPase, H+ transporting, lysosomal 50/57 kDa, V1 subunit H | Atp6v1h | Component of a vacuolar type H+ ATPase that acidifies granule lumen for condensation of granule contents (Borges 2011) | 0.52 | 0.00016 |
ATPase, H+ transporting, lysosomal V0 subunit a2 | Atp6v0a2 | Component of a vacuolar type H+ ATPase that acidifies granule lumen for condensation of granule contents (Borges 2011) | 0.46 | 0.00016 |
ATPase, H+ transporting, lysosomal 50/57 kDa, V1 subunit H | Atp6v1a | Component of a vacuolar type H+ ATPase that acidifies granule lumen for condensation of granule contents (Borges 2011) | 0.42 | 0.020 |
ATPase, H+ transporting, lysosomal 9 kDa, V0 subunit e1 | Atp6v0e | Component of a vacuolar type H+ ATPase that acidifies granule lumen for condensation of granule contents (Borges 2011) | 0.32 | 0.0044 |
ATPase, H+ transporting, lysosomal 34 kDa, V1 subunit D | Atp6v1d | Component of a vacuolar type H+ ATPase that acidifies granule lumen for condensation of granule contents (Borges 2011) | −0.24 | 0.038 |
ATPase, H+ transporting, lysosomal 13 kDa, V1 subunit G2 | Atp6v1g2 | Component of a vacuolar type H+ ATPase that acidifies granule lumen for condensation of granule contents (Borges 2011) | −1.84 | 0.00016 |
Lysosomal trafficking regulator | Lyst | Important regulator of granule formation (Durchfort 2012 [95], Hammel 2010 [52]) | −1.29 | 0.00016 |
Solute carrier family 18, member 2 | Slc18a2 | Transports histamine and serotonin into granules (Merickel 1995 [96]) | −0.92 | 0.00016 |