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Table 2 Expression of genes in female BMMCs relative to male BMMCs, involving granule biogenesis and maturation

From: Sexual dimorphism in the mast cell transcriptome and the pathophysiological responses to immunological and psychological stress

Gene name Gene symbol Comments Statistics
Log2 fold change q value
Spermidine synthetase Srm Synthesizes polyamines important in granule biogenesis and homeostasis, including storage of histamine and proteases (Garcia-Faroldi, 2010 [47]) 3.68 0.00016
Ornithine decarboxylase 1 Odc1 Synthesizes polyamines important in granule biogenesis and homeostasis, including storage of histamine and proteases (Garcia-Faroldi, 2010 [47]) 2.52 0.00016
Spermine synthetase Sms Synthesizes polyamines important in granule biogenesis and homesostasis, including storage of histamine and proteases (Garcia-Faroldi, 2010 [47]) 0.54 0.0045
Basic helix-loop-helix family, member A15 Bhlha15 Important transcription factor in forming mature secretory granules in a variety of specialized secretory cells (Tian 2010 [72]) 3.42 0.00016
Rab5c, member of Ras oncogene family Rab5c Key regulator of mast cell granule fusion during biogenesis (Azouz 2014 [48]) 0.62 0.00032
Mannose-6-phosphate receptor M6pr Transports glycosylated proteins, such as lysosomal hydrolases and TNF, into vesicles (Coutinho 2012 [50], Olszewski 2006 [73]) 0.43 0.00016
Adaptor protein 1A complex Ap1m1 Protein necessary for the sorting of proteins into vesicles and secretory granule maturation (Bonnemaison 2014 [49]) 0.36 0.0033
ATPase, H+ transporting, lysosomal 16 kDa, V0 subunit c Atp6v0c Component of a vacuolar type H+ ATPase that acidifies granule lumen for condensation of granule contents (Borges 2011) 0.69 0.00016
ATPase, H+ transporting, lysosomal 50/57 kDa, V1 subunit H Atp6v1h Component of a vacuolar type H+ ATPase that acidifies granule lumen for condensation of granule contents (Borges 2011) 0.52 0.00016
ATPase, H+ transporting, lysosomal V0 subunit a2 Atp6v0a2 Component of a vacuolar type H+ ATPase that acidifies granule lumen for condensation of granule contents (Borges 2011) 0.46 0.00016
ATPase, H+ transporting, lysosomal 50/57 kDa, V1 subunit H Atp6v1a Component of a vacuolar type H+ ATPase that acidifies granule lumen for condensation of granule contents (Borges 2011) 0.42 0.020
ATPase, H+ transporting, lysosomal 9 kDa, V0 subunit e1 Atp6v0e Component of a vacuolar type H+ ATPase that acidifies granule lumen for condensation of granule contents (Borges 2011) 0.32 0.0044
ATPase, H+ transporting, lysosomal 34 kDa, V1 subunit D Atp6v1d Component of a vacuolar type H+ ATPase that acidifies granule lumen for condensation of granule contents (Borges 2011) −0.24 0.038
ATPase, H+ transporting, lysosomal 13 kDa, V1 subunit G2 Atp6v1g2 Component of a vacuolar type H+ ATPase that acidifies granule lumen for condensation of granule contents (Borges 2011) −1.84 0.00016
Lysosomal trafficking regulator Lyst Important regulator of granule formation (Durchfort 2012 [95], Hammel 2010 [52]) −1.29 0.00016
Solute carrier family 18, member 2 Slc18a2 Transports histamine and serotonin into granules (Merickel 1995 [96]) −0.92 0.00016