Fig. 5
Female mast cells contain more granule-associated mediators than male mast cells. a The total tryptic activity of unstimulated female BMMCs was higher than that of male BMMCs (21.2 vs. 14.5; P < 0.01; n = 5). b The total chymase activity of unstimulated female BMMCs was higher than that of male BMMCs (9.0 vs. 6.4; P < 0.01; n = 3). c The total histamine content of unstimulated female BMMCs was higher than that of male BMMCs (827.7 vs. 487.8; P < 0.05; n = 5). d The total histamine content of female mouse pMCs was higher than that of male pMCs (35,489 vs. 22,673; P < 0.01; n = 7/male, n = 11/female). e The total histamine content of pMCs from female rats was higher than that of male rat pMCs (71,806 vs. 43,167; P < 0.001 n = 3). f Representative images of peritoneal mast cells recovered and pooled from five, 8-week-old male and female C57BL/6 mice and analyzed by TEM. Scale bar = 2 μm. All values were normalized to cell number. Values represent mean ± SE. *P < 0.05, **P < 0.01, ***P < 0.001 vs. males