Impact of gonadectomy on blood pressure regulation in ageing male and female rats

Table 3 Spectral power analysis of the SBP and sBRG in normotensive intact and gonadectomised rats

Variable	F-INTACT (n = 7)	F-GONADX (n = 7)	M-INTACT (n = 8)	M-GONADX (n = 5)	Two-way ANOVA
TP mmHg^2/Hz	0.24 ± 0.03	0.27 ± 0.03	0.21 ± 0.03	0.32 ± 0.03	Sham < GONADX*
VLF mmHg^2/Hz (0–0.26 Hz)	0.06 ± 0.02	0.09 ± 0.02	0.09 ± 0.02	0.11 ± 0.02	NS
LF mmHg^2/Hz (0.26–0.76 Hz)	0.09 ± 0.02	0.12 ± 0.02	0.06 ± 0.02	0.12 ± 0.02	Sham < GONADX*
HF mmHg^2/Hz (0.76–3.3 Hz)	0.08 ± 0.01	0.07 ± 0.01	0.05 ± 0.01	0.08 ± 0.01	SexGONADX*
LF:HF	1.1 ± 0.2	1.7 ± 0.2	1.6 ± 0.2	1.5 ± 0.2	Sex*GONADX P = 0.08
VLF % (SBP)	25.7 ± 5.3	30.6 ± 5.3	43.3 ± 4.4	35.8 ± 5.3	F < M*
LF % (SBP)	36.8 ± 4.0	42.5 ± 4.0	34.3 ± 3.4	37.9 ± 4.0	NS
HF % (SBP)	37.5 ± 3.4	26.9 ± 3.4	22.4 ± 2.8	26.3 ± 3.4	F > M; SexGONADX*
Respiratory rate 24 h (breath per min)	96.3 ± 3.7	91.8 ± 4.0	76.5 ± 3.2	78.1 ± 4.0	F > M***
sBRG (+)	1.1 ± 0.1	1.2 ± 0.1	1.3 ± 0.1	1.5 ± 0.1	F < M*
sBRG (−)	−1.5 ± 0.2	−1.8 ± 0.1	−1.9 ± 0.2	−2.3 ± 0.2	F < M*

Data analysed by Spike2 v 8.02c (CED, Cambridge, UK). The two-way ANOVA assessed the effect of sex steroids and surgery, with Tukey HSD post hoc analysis. Data are presented as mean ± SEM
TP total spectrum power, VLF very low frequency spectrum, LF low-frequency spectrum, HF high-frequency spectrum, SBP systolic blood pressure, sBRG (+) positive ramp of spontaneous baroreflex gain, sBRG (−) negative ramp of spontaneous baroreflex gain, NS non-significant
*P < 0.05; **P < 0.01;***P < 0.001

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