Fig. 1

Arterial pressures, pulse pressure, heart rate, and locomotor activity in male and female mice at 3, 5, 14, and 18 months of age. a Mean arterial pressure (MAP), b pulse pressure (PP), c systolic arterial pressure (SAP), d diastolic arterial pressure (DAP), e heart rate (HR), and f locomotor activity in male (blue bars) and female (red bars) mice. Data were analyzed using a two-way ANOVA with the factors sex, age, and their interaction. Tukey’s post hoc tests were performed where appropriate. *P < 0.05, **P < 0.01 as compared to age-matched male. ^# P < 0.05, ^## P < 0.01, ^### P < 0.001 as compared to 3-month-old counterpart. ^† P < 0.05, ^††† P < 0.001 as compared to 5-month-old counterpart. ^§ P < 0.05 as compared to 14-month-old counterpart