Fig. 5
The effects of sex-related factors on expression of GABA- and BDNF-related genes in the basolateral amygdala of stressed adult mice. a Mice with male sex chromosome complement (XY) had lower expression of Sst. Additionally, mice treated with testosterone had higher Sst expression. There were no main effects of sex chromosome complement on expression of Gad67 (b), Gad65 (c), TrkB (d), or Bdnf (e). There were no main effects of gonadal sex on gene expression (a–e). Testosterone significantly decreased expression of Bdnf (e), but did not affect expression of Gad67 (b), Gad65 (c), or TrkB (d). There was a significant three-way sex chromosome complement × gonadal sex × hormone interaction on expression of Gad67 (b, left) and Gad65 (c, left). Specifically, the post hoc analyses revealed a significant interaction of gonadal sex and hormone only in XY mice. Graphs on the left show results individually for all eight experimental groups. For each gene, graphs on the right summarize the same data as shown on the left after collapsing across main effects. Numbers at the base of the bars indicate N. For main effect comparisons: *p < 0.05. For interaction between gonadal sex and hormone: δ p < 0.05. T testosterone, B blank, F gonadal female, M gonadal male