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Table 2 Population kinetic parameters in the final model

From: The elimination half-life of crystalloid fluid is shorter in female than in male volunteers: a retrospective population kinetic analysis

  Covariate Best estimate 2.5 % CI 97.5 % CI CV%
Kinetic parameter
 tvVc (ml) 2521 2185 2858 6.8
 tvk 12 (10−3 min−1) 84.0 70.7 97.2 8.0
 tvk 21 (10−3 min−1) 54.8 46.3 63.4 8.0
 tvk 10 (10−3 min−1) 28.2 24.4 31.6 6.1
 tvk b (10−3 min−1)   9.0 7.1 10.9 10.7
Covariate effects
 tvV c Dose/min/kg 0.39 0.23 0.55 21.2
 tvV c Male gender 0.51 0.37 0.64 13.4
 tvk 21 Male gender 0.50 0.30 0.71 20.8
 tvk 10 Male gender −0.44 −0.63 −0.27 −19.9
  1. tv typical value, CI confidence interval, CV coefficient of variation