Table 2 Population kinetic parameters in the final model

 tvV_c (ml)

–

2521

2185

2858

6.8

 tvk ₁₂ (10⁻³ min⁻¹)

–

84.0

70.7

97.2

8.0

 tvk ₂₁ (10⁻³ min⁻¹)

–

54.8

46.3

63.4

8.0

 tvk ₁₀ (10⁻³ min⁻¹)

–

28.2

24.4

31.6

6.1

 tvk _b (10⁻³ min⁻¹)

9.0

7.1

10.9

10.7

 tvV _c

Dose/min/kg

0.39

0.23

0.55

21.2

 tvV _c

Male gender

0.51

0.37

0.64

13.4

 tvk ₂₁

Male gender

0.50

0.30

0.71

20.8

 tvk ₁₀

Male gender

−0.44

−0.63

−0.27

−19.9