The elimination half-life of crystalloid fluid is shorter in female than in male volunteers: a retrospective population kinetic analysis

Table 1 Demographic data for the cohorts used for population volume kinetic analysis

Study no.	Females/males	Infusions	Age (years)	Body weight (kg)	Fluid volume (ml/kg)	Infusion time (min)	Infusion rate (ml/min/kg)	Study length (min)	Reference no.
1	0/10	10	22 (18–28)	79 (65–101)	20	30	0.666	180	[9]
2	10/0	10	29 (21–39)	63 (58–67)	25	30	0.833	240	[10]
3	0/10	10	32 (24–44)	81 (72–95)	25	30	0.833	240	[11]
4	0/10	19^a	22 (19–37)	80 (75–100)	5, 10	15	0.333, 0.666	120	[12]
5	0/10	19^a	31 (28–40)	82 (70–97)	25	15, 30	0.83, 1.66	90	[13]
6	8/0	31^b	32 (23–46)	61 (52–75)	15, 25	15, 30, 45, 80	0.31, 0.42, 0.55, 0.83, 1.66	135, 150, 165, 310	[14]
7	0/12	12	30 (20–38)	84 (71–98)	25	30	0.833	240	None

Data are the mean (range)
^aEach male underwent two infusions with different volume or rate. One experiment in one male was excluded due to missed urinary excretion
^bSix volunteers underwent three to six infusions and two received one infusion each

ISSN: 2042-6410