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Fig. 6 | Biology of Sex Differences

Fig. 6

From: Sex-specific phenotypes of hyperthyroidism and hypothyroidism in mice

Fig. 6

TH effects in brown adipose tissue (BAT), heart, and liver of male and female mice. Fold changes of representative TH-responsive genes were measured by quantitative RT-PCR in a BAT, d heart, and g liver tissue of hyperthyroid or hypothyroid mice of both sexes and normalized to tissue samples of euthyroid control mice. For BAT Dio2, Ucp1, and PGC1α expression; for heart Dio2, Myh6, and Hcn4 expression; and for liver Dio1, Tbg, and Me1 expression were quantified. Additionally, mRNA expression of TH transporter genes were analyzed in b BAT, e heart, and h liver. For BAT: Mct8, Mct10, Oatp3a1, Lat2, for heart: Mct8, Ntcp, Lat1, Lat2, and for liver: Mct8, Mct10, Lat1, Lat2. Furthermore, euthyroid sex comparison was analyzed in c BAT, f heart, and i liver of all genes, and gene expression in female tissues was normalized to male samples. Data are presented as mean ± SD, N = 5–7 animals/sex/treatment; unpaired Student’s t test, *p < 0.05, **p < 0.01, ***p < 0.001 represent t test results

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