From: Sex-related differences in pain behaviors following three early life stress paradigms
Phase | Treatment | 0Â mmHg | 20Â mmHg | 40Â mmHg | 60Â mmHg |
---|---|---|---|---|---|
Metestrus/diestrus | Control | 1.1 ± 0.3 | 5.1 ± 1.6 | 16.4 ± 3.1 | 27.3 ± 3.3 |
 | Maternal separation | 4.3 ± 1.4 | 8.3 ± 1.6 | 17.0 ± 2.4 | 28.8 ± 1.2 |
 | Control | 0.6 ± 0.2 | 2.9 ± 0.8 | 13.3 ± 0.7 | 23.6 ± 1.9 |
 | Limited nesting | 0.5 ± 0.3 | 3.5 ± 1.3 | 15.8 ± 0.9 | 23.3 ± 1.4 |
 | Odor only | 0.2 ± 0.2 | 2.5 ± 0.8 | 12.2 ± 1.5 | 21.2 ± 1.5 |
 | Predictable | 1.1 ± 0.3 | 4.7 ± 0.6 | 12.1 ± 1.3 | 19.4 ± 0.9 |
 | Unpredictable | 0.5 ± 0.3 | 5.3 ± 1.3 | 14.8 ± 3.3* | 27.0 ± 3.7* |
Proestrus/estrus | Control | 3.6 ± 2.1 | 8.0 ± 3.0 | 20.8 ± 4.1 | 34.6 ± 4.9 |
 | Maternal separation | 3.3 ± 0.9 | 7.1 ± 0.9 | 19.6 ± 2.1 | 30.9 ± 3.1 |
 | Control | 0.6 ± 0.6 | 3.0 ± 1.3 | 17.4 ± 0.6*** | 26.6 ± 1.3** |
 | Limited nesting | 0.9 ± 0.5 | 1.8 ± 0.4 | 18.9 ± 0.9 | 26.4 ± 2.4 |
 | Odor only | 0.5 ± 0.3 | 3.5 ± 1.0 | 13.8 ± 6.3 | 27.3 ± 1.3 |
 | Predictable | 3.8 ± 2.2 | 5.5 ± 0.3 | 23.0 ± 3.3*** | 27.0 ± 1.7*** |
 | Unpredictable | 1.0 ± 0.4 | 5.2 ± 1.0 | 22.0 ± 0.9 | 32.5 ± 2.6* |