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Table 3 Visceral sensitivity in adult female animals following ELS across the estrus cycle

From: Sex-related differences in pain behaviors following three early life stress paradigms

Phase

Treatment

0 mmHg

20 mmHg

40 mmHg

60 mmHg

Metestrus/diestrus

Control

1.1 ± 0.3

5.1 ± 1.6

16.4 ± 3.1

27.3 ± 3.3

 

Maternal separation

4.3 ± 1.4

8.3 ± 1.6

17.0 ± 2.4

28.8 ± 1.2

 

Control

0.6 ± 0.2

2.9 ± 0.8

13.3 ± 0.7

23.6 ± 1.9

 

Limited nesting

0.5 ± 0.3

3.5 ± 1.3

15.8 ± 0.9

23.3 ± 1.4

 

Odor only

0.2 ± 0.2

2.5 ± 0.8

12.2 ± 1.5

21.2 ± 1.5

 

Predictable

1.1 ± 0.3

4.7 ± 0.6

12.1 ± 1.3

19.4 ± 0.9

 

Unpredictable

0.5 ± 0.3

5.3 ± 1.3

14.8 ± 3.3*

27.0 ± 3.7*

Proestrus/estrus

Control

3.6 ± 2.1

8.0 ± 3.0

20.8 ± 4.1

34.6 ± 4.9

 

Maternal separation

3.3 ± 0.9

7.1 ± 0.9

19.6 ± 2.1

30.9 ± 3.1

 

Control

0.6 ± 0.6

3.0 ± 1.3

17.4 ± 0.6***

26.6 ± 1.3**

 

Limited nesting

0.9 ± 0.5

1.8 ± 0.4

18.9 ± 0.9

26.4 ± 2.4

 

Odor only

0.5 ± 0.3

3.5 ± 1.0

13.8 ± 6.3

27.3 ± 1.3

 

Predictable

3.8 ± 2.2

5.5 ± 0.3

23.0 ± 3.3***

27.0 ± 1.7***

 

Unpredictable

1.0 ± 0.4

5.2 ± 1.0

22.0 ± 0.9

32.5 ± 2.6*

  1. Mean ± SEM
  2. *p < 0.05 vs same cycle control, **p < 0.05 metestrus/diestrus vs proestrus/estrus within same group