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Fig. 4 | Biology of Sex Differences

Fig. 4

From: Characterization of osteoarthritic human knees indicates potential sex differences

Fig. 4

Phenotypic characteristics of female and male chondrocytes isolated from osteoarthritic knees. ad Passage 1 chondrocytes were treated with 10−8 M 1α,25(OH)2D3 or 10−8 M E2. eh Alkaline phosphatase specific activity (a, e) was measured in whole cell lysates. mRNAs for chondrocyte genes aggrecan (b, f), type-II collagen (c, g), and cartilage oligomatric matrix protein (d, h) were measured using real-time qPCR. Data show treatment versus vehicle control ratios of 6 male and 6 female donors. The dashed line represents the vehicle control (dashed line = 1). * p < 0.05 vs. control; p < 0.05 vs. male

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