Fig. 4

Metabolic changes in males, females, and females that were androgenized (AF) on postnatal day (PND) 1. At PND10, there were significant differences in a the percentage of inguinal adipose tissue (IngAT) and serum b leptin, c adiponectin, and d interleukin (IL) 6 levels. At PND90, there were significant differences in e body weight, f glycemia and serum, g insulin, h leptin and i IL1β levels. The mRNA levels of j leptin, k adiponectin, l IL6, and m TNFα in perigonadal adipose tissue at PND90 were also affected. #p < 0.0001, ##p < 0.002, ###p < 0.0002, *p < 0.01, ***p < 0.005, @p < 0.05. PND10: inguinal adipose tissue: N = 10; serum leptin and IL6 levels: N = 6; serum adiponectin: M and F: N = 8, AF: N = 9. PND90: body weight and glycemia: M: N = 8, F: N = 12, AF: N = 11; serum insulin, leptin, and Il1β levels: N = 6; mRNA levels for leptin, adiponectin, IL6, and TNFα: N = 6