Fig. 4

Effects of in vitro administration of SP-A1 and SP-A2 to the distribution of alveolar macrophages. a Donut charts of the distribution of the alveolar macrophage phenotypes following administration of the indicated doses of SP-A protein(s) for 60 min. The number of cells counted per genotype can be seen in the donut hole. b Statistic comparisons of data from panel a showing sex differences were performed in SAS with a hierarchical model accounting for cells from the same animal and cells that were cultured within the same well. c Data from panel a were replotted to show statistical comparisons of data for male mice showing differences among SP-A protein treatment regimes. d Data from panel a were replotted to show statistical comparisons of data for female mice showing differences among SP-A protein treatment regimes. *P ≤ 0.05; ***P ≤ 0.001