Table 3 Two-way ANOVA for univariate and pairwise comparisons between gender, estrous cycle stages, and exposure for IL6R expression
From: Sex-specific IL-6-associated signaling activation in ozone-induced lung inflammation
Univariate tests: dependent variable: IL6R | |||||||
|  |  |  | df | F | Sig. | Partial η2 | |
Analysis of gender and exposure | Exposure | FA | 1, 52 | 4.275 | 0.044 | 0.076 | |
Ozone | 1, 52 | 44.137 | <0.0005 | 0.459 | |||
Sex | F | 1, 52 | 70.840 | <0.0005 | 0.577 | ||
M | 1, 52 | 0.087 | 0.770 | 0.002 | |||
Analysis of female estrous cycle stages and exposure | Estrous cycle stage | Non-proestrus | 1, 24 | 150.946 | <0.0005 | 0.863 | |
Proestrus | 1, 24 | 141.524 | <0.0005 | 0.855 | |||
Exposure | FA | 1, 24 | 10.240 | 0.004 | 0.299 | ||
Ozone | 1, 24 | 7.898 | 0.010 | 0.248 | |||
Pairwise comparisons: dependent variable: IL6R | |||||||
|  |  |  | (I) Sex | (J) Sex | Mean difference (I–J) | 95 % CI for difference | |
Lower bound | Upper bound | ||||||
Analysis of gender and exposure | Exposure | FA | M | F | 0.439 | 0.013 | 0.864 |
Ozone | F | M | 1.409 | 0.984 | 1.835 | ||
Sex | F | Ozone | FA | 1.785 | 1.360 | 2.211 | |
M | FA | Ozone | 0.062 | 0.363 | 0.488 | ||
Analysis of female estrous cycle stages and exposure | Estrous cycle stage | Non-proestrus | Ozone | FA | 2.529 | 2.104 | 2.954 |
Proestrus | Ozone | FA | 2.449 | 2.024 | 2.874 | ||
Exposure | FA | Proestrus | Non-proestrus | 0.659 | 0.234 | 1.084 | |
Ozone | Proestrus | Non-proestrus | 0.579 | 0.154 | 1.003 | ||