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Table 10 Two-way ANOVA for univariate and pairwise comparisons between gender, estrous cycle stages and exposure for AKT1 expression

From: Sex-specific IL-6-associated signaling activation in ozone-induced lung inflammation

Univariate tests: dependent variable: AKT1
    df F Sig. Partial η2
Analysis of gender and exposure Exposure FA 1,52 0.001 0.996 0.002
Ozone 1,52 121.354 <0.0005 0.700
Sex F 1,52 64.526 <0.0005 0.554
M 1,52 8.929 0.004 0.147
Analysis of female estrous cycle stages and exposure Estrous cycle stage Non-proestrus 1,24 179.278 <0.0005 0.882
Proestrus 1,24 511.045 <0.0005 0.955
Exposure FA 1,24 3.261 0.084 0.120
Ozone 1,24 54.923 <0.0005 0.696
Pairwise comparisons: dependent variable: AKT1
    (I) Sex (J) Sex Mean difference (I–J) 95 % CI for difference
Lower bound Upper bound
Analysis of gender and exposure Exposure FA F M 0.001 0.167 0.168
Ozone F M 0.919 0.751 1.086
Sex F Ozone FA 0.670 0.503 0.837
M FA Ozone 0.249 0.082 0.417
Analysis of female estrous cycle stages and exposure Estrous cycle stage Non-proestrus Ozone FA 1.121 0.948 1.293
Proestrus Ozone FA 1.892 1.719 2.065
Exposure FA Non-proestrus Proestrus 0.151 0.022 0.324
Ozone Proestrus Non-proestrus 0.620 0.448 0.793