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Table 1 Two-way ANOVA for univariate and pairwise comparisons between gender, estrous cycle stages, and exposure for IL6 expression

From: Sex-specific IL-6-associated signaling activation in ozone-induced lung inflammation

Univariate tests: dependent variable: IL6
    df F Sig. Partial η2
Analysis of gender and exposure Exposure FA 1, 52 0.751 0.390 0.014
Ozone 1, 52 20.113 <0.0005 0.279
Sex F 1, 52 438.088 <0.0005 0.894
M 1, 52 299.716 <0.0005 0.852
Analysis of female estrous cycle stages and exposure Estrous cycle stage Non-proestrus 1, 24 55.368 <0.0005 0.698
Proestrus 1, 24 108.679 <0.0005 0.819
Exposure FA 1, 24 5.228 0.031 0.179
Ozone 1, 24 27.777 <0.0005 0.536
Pairwise comparisons: dependent variable: IL6
    (I) Sex (J) Sex Mean difference (I–J) 95 % CI for difference
Lower bound Upper bound
Analysis of gender and exposure Exposure FA F M 0.109 0.144 0.363
Ozone F M 0.566 0.313 0.819
Sex F Ozone FA 2.641 2.388 2.895
M Ozone FA 2.185 1.932 2.438
Analysis of female estrous cycle stages and exposure Estrous cycle stage Non-proestrus Ozone FA 1.758 1.270 2.245
Proestrus Ozone FA 2.462 1.975 2.950
Exposure FA Proestrus Non-proestrus .540 0.053 1.028
Ozone Proestrus Non-proestrus 1.245 0.757 1.732