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Fig. 3 | Biology of Sex Differences

Fig. 3

From: Sex-specific IL-6-associated signaling activation in ozone-induced lung inflammation

Fig. 3

JAK2 and JAK2 phosphorylated (Y1007+Y1008) expression and effect of ozone exposure. Left panels: a Representative Western blot images of JAK2 and JAK2 phosphorylated (Y1007+Y1008) expression in males and females with filter air and O3 exposure; univariate analysis of JAK2 (b) and JAK2 (e) phosphorylated (Y1007+Y1008), expression in males and females, with FA and O3 exposure; two-way ANOVA interaction effect of sex (c) and exposure (d), for JAK2 expression and sex (f) and exposure (g), for JAK2 phosphorylated (Y1007+Y1008) expression. Right panels: h Representative Western blot images of JAK2 and JAK2 phosphorylated (Y1007+Y1008) expression in estrous cycle stages of females, with filter air and O3 exposure; univariate analysis of i JAK2 and l JAK2 phosphorylated (Y1007+Y1008), expression in estrous cycle stages of females, with FA and O3 exposure. Two-way ANOVA interaction effect of exposure (j) and estrous cycle stages (k), for JAK2 expression and exposure (m) and estrous cycle stages (n) and for JAK2 phosphorylated (Y1007+Y1008) expression. Univariate analysis data expressed as Ranks-Kruskal-Wallis test of densitometric analysis; the values are depicted as mean with SD, where *p ≤ 0.05 and **p ≤ 0.01 are the levels of statistical significance compared to controls (n = 6–8 per group). Two-way ANOVA for JAK2 and JAK2 phosphorylated (Y1007+Y1008) analysis is given in Tables 7 and 8, respectively

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