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Fig. 2 | Biology of Sex Differences

Fig. 2

From: Sex-specific IL-6-associated signaling activation in ozone-induced lung inflammation

Fig. 2

STAT3, STAT3 Serine 727, and STAT3 Tyrosine 705 phosphorylation and effect of ozone exposure. Left panels: a Representative Western blot images of STAT3, STAT3 Serine 727 and STAT3 Tyrosine 705 phosphorylation expression in males and females with filter air and O3 exposure; univariate analysis of STAT3 (b), STAT3 Serine 727 (e), and STAT3 Tyrosine 705 (h), expression in males and females, with FA and O3 exposure; Two-way ANOVA interaction effect of sex (c) and exposure (d), for STAT3 expression, sex (f) and exposure (g), for STAT3 Serine 727 expression and sex (i) and exposure (j), for STAT3 Tyrosine 705 expression. Right panels: k Representative Western blot images of STAT3, STAT3 Serine 727, and STAT3 Tyrosine 705 phosphorylation expression in estrous cycle stages of females, with filter air and O3 exposure; univariate analysis of STAT3 (l), STAT3 Serine 727 (o), and STAT3 Tyrosine 705 (r), expression in estrous cycle stages of females, with FA and O3 exposure. Two-way ANOVA interaction effect of exposure (m) and estrous cycle stages (n), for STAT3 expression, exposure (p) and estrous cycle stages (q), for STAT3 Serine 727 expression, and exposure (s) and estrous cycle stages (t), for STAT3 Tyrosine 705 expression. Univariate analysis data expressed as Ranks-Kruskal-Wallis test of densitometric analysis; the values are depicted as mean with SD, where *p ≤ 0.05 and **p ≤ 0.01 are the levels of statistical significance compared to controls (n = 6–8 per group). Two-way ANOVA for STAT3, STAT3 Serine 727, and STAT3 Tyrosine 705 phosphorylation expression analysis is given in Tables 4, 5, and 6, respectively

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