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Fig. 1 | Biology of Sex Differences

Fig. 1

From: Sex-specific IL-6-associated signaling activation in ozone-induced lung inflammation

Fig. 1

IL6 and IL6R expression and effect of ozone exposure. Left panels: a Representative Western blot images of IL6 and IL6R expression in males and females with filter air and O3 exposure; univariate analysis of IL6 (b) and IL6R (e), expression in males and females, with FA and O3 exposure; two-way ANOVA interaction effect of sex (c) and exposure (d), for IL6 expression and sex (f) and exposure (g), for IL6R expression. Right panels: h Representative Western blot images of IL6 and IL6R expression in estrous cycle stages of females, with filter air and O3 exposure; univariate analysis of IL6 (i) and IL6R (l), expression in estrous cycle stages of females, with FA and O3 exposure. Two-way ANOVA interaction effect of exposure (j) and estrous cycle stages (k), for IL6 expression and exposure (m) and estrous cycle stages (n), for IL6R expression. Univariate analysis data expressed as Ranks-Kruskal-Wallis test of densitometric analysis; the values are depicted as mean with SD, where *p ≤ 0.05, **p ≤ 0.01, and ***p ≤ 0.001 are the levels of statistical significance compared to controls (n = 6–8 per group). Two-way ANOVA for IL6 and IL6R analysis is given in Tables 1 and 3, respectively

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