Skip to main content

Table 4 Summary of the analysis of biochemical data

From: Consecutive lynestrenol and cross-sex hormone treatment in biological female adolescents with gender dysphoria: a retrospective analysis

Test

Method of measurement

L0

L6m

P (L0–6 m)

L12m

P (L0–12 m)

L+T0

L+T6m

P (L+T0–6 m)

L+T12m

P (L+T0–12 m)

Hemoglobin

Spectrophotometry (Sysmex XE-5000)

133.7

142.4

<0.001

141.4

0.001

143.3

148.5

<0.001

149.7

<0.001

Reference (g/L): M < 18 y: 130–160, M > 18 y: 129–173, F < 18 y: 120–160, F > 18 y: 118–148

Hematocrit

DC impendance (Sysmex XE-5000)

0.400

0.417

<0.001

0.418

0.003

0.419

0.435

0.002

0.438

<0.001

Reference (proportion of 1.0): M < 18 y: 0.37–0.49, M > 18 y: 0.39–0.497, F < 18 y: 0.36–0.46, F > 18 y: 0.358–0.437

Creatinine

Rate-blanked Jaffé kinetic assay (Roche Diagnostics c701 (a + b))

65.416

71.604

<0.001

70.72

<0.001

69.836

73.372

0.052

72.488

0.045

Reference (μmol/L): M/F: 11–13 y: 46.852–69.836, M/F: 13–15 y: 50.388–76.908, M > 15 y: 63.648–103.428, F > 15 y: 48.62–84.864

Aspartate amino transferase

UV-kinetic (IFCC) method without pyridoxal phosphate (Roche Diagnostics Cobas c701)

0.30

0.31

0.903

0.33

0.091

0.31

0.35

0.031

0.35

0.003

Reference (μkat/L): M 0–0.62, F 0–0.52

Alanine amino transferase

UV-kinetic (IFCC) method without pyridoxal phosphate (Roche Diagnostics Cobas c701)

0.22

0.27

0.121

0.31

0.012

0.28

0.31

0.079

0.34

0.045

Reference (μkat/L): M 0.12–0.67, F 0.12–0.52

Triglycerides

Enzymatic colorimetric method (GPO-PAP and CHOD-PAP, Roche Diagnostics c701 (a + b))

0.838

0.870

0.31

0.661

0.128

0.651

0.934

0.18

1.394

0.18

Reference (mmol/L): M 10–15 y: 0.362–1.413, M 15–20 y: 0.418–1.672, F 10–15 y: 0.418–1.48; F 15–20 y: 0.441–1.492

Total cholesterol

Enzymatic colorimetric method (GPO-PAP and CHOD-PAP, Roche Diagnostics c701 (a + b))

4.153

4.348

0.182

4.237

0.218

4.212

4.099

0.504

4.450

0.11

Reference (mmol/L): M 10–15 y: 3.082–5.232, M 15–20 y: 2.927–5.102, F 10–15 y: 3.212–5.206, F 15–20 y: 3.108–5.258

High density lipoprotein

Enzymatic colorimetric method (Roche Diagnostics c701 (a + b))

1.481

1.096

<0.001

1.017

0.002

1.098

1.194

0.419

1.085

0.77

Reference (mmol/L): M: 0.829–1.865, F: 1.010–2.486

Low density lipoprotein

Calculated

2.379

3.057

0.001

2.750

0.043

2.794

2.267

NA

3.163

0.09

Reference (mmol/L): M < 20 y: 1.606–3.626, F < 20 y: 1.735–3.626

Hemoglobin A1c

Ion-exchange chromatography (Tosoh HLV-723G8)

0.052

0.051

0.228

0.052

0.34

0.051

0.052

0.102

0.051

0.317

Reference (proportion of 1.0): M/F 0.04–0.055

Homeostasis Model Assessment insulin resistance

Calculated

2.99

3.11

0.122

2.43

0.396

2.45

4.84

NA

7.44

0.185

Reference: M during puberty <5.22, F during puberty <3.82 or M/F <4.39 [55, 56]

Thyroid-stimulating hormone

Electro-chemoluminescence assay (Roche Diagnostics E170 Modular)

2.07

2.06

0.757

2.1

0.257

2.25

1.83

0.013

2.22

0.271

Reference (mIU/L): M/F 11–20 y: 0.51–4.3

Free thyroxin

Electro-chemoluminescence assay (Roche Diagnostics E170 Modular)

15.959

17.375

0.006

19.820

<0.001

18.275

16.216

0.001

14.543

0.003

Reference (pmol/L): M/F 12-20 y: 12.613-20.978

Lutheinizing hormone

Electro-chemoluminescence assay (Roche Diagnostics E170 Modular)

7.56

4.63

0.065

2.58

0.042

3.41

1.93

0.004

1.68

0.028

Reference (IU/L): M 1–9 U/L, F 1–96 U/L (cycle dependant)

Follicular-stimulating hormone

Electro-chemoluminescence assay (Roche Diagnostics E170 Modular)

5.15

5.18

0.785

4.36

0.623

4.96

2.95

0.001

2.56

0.019

Reference (IU/L): M 1–12 U/L, F 2–22 U/L (cycle dependant)

Sex hormone-binding globulin

Electro-chemoluminescence assay (Roche Diagnostics E170 Modular)

77.14

20.88

<0.001

19.15

0.001

30.34

25.27

0.279

23.51

0.279

Reference (nmol/L): M < 70 y: 11.6–71.2, F < 50 y: 10.5–163.7

Estradiol

Electro-chemoluminescence assay (Roche Diagnostics E170 Modular)

277.564

119.895

0.002

120.225

0.122

117.802

175.841

0.107

156.348

0.701

Reference (pmol/L): M 99.484–191.626, F 98.016–1152.694 (cycle dependant)

Testosterone

liquid chromatography tandem mass spectrometry (LC/MSMS)

0.950

0.667

0.002

0.663

0.687

0.844

15.559

<0.001

19.532

0.001

Reference (nmol/L): M 11.139–34.874, F < 50 y 0.291–1.669

Free testosterone

Calculated

15.962

24.290

0.209

21.861

0.138

25.678

295.297

0.005

472.614

0.008

Reference (pmol/L): M 208.2–867.5, F 0.694–22.208

Anti-Müllerian hormone

Enzyme-linked immunosorbent assay (Beckman Coulter Company) until 2/2015, thereafter electro-chemoluminescence assay (Roche Diagnostics E170 Modular)

33.214

25.714

0.066

24.000

0.423

24.357

28.429

0.18

27.072

0.575

Reference (pmol/L): M 6–20 y 11.429–1028.578 (Tanner), F 8–20 y: 4.7143–60.143

  1. L0 mean values before initiation of L, L6m mean values after 6 months of L, P(L0–6 m) P values of comparison of baseline parameters with values after 6 months of L, L12m mean values after 12 months of L, P(L0–12 m) P values of comparison of baseline parameters with values after 12 months of L, L+T0 mean values before initiation of L+T, L+T6m mean values after 6 months of L+T, P(L+T0–6 m) P values of comparison of baseline parameters with values after 6 months of L+T, L+T12m mean values after 12 months of L+T, P(L+T0–12 m) P values of comparison of baseline parameters with values after 12 months of L+T, NA not available due to insufficient data, L lynestrenol monotherapy, L+T lynestrenol and testosterone esters combination therapy, M male reference, F female reference, Y years old, cycle dependant different reference ranges according to different stages of menstrual cycle (maximum upper and lower limit of all cycle stages are represented), Tanner different reference ranges according to different Tanner stages (maximum upper and lower limit of all Tanner stages are represented)
Back to article page

Biology of Sex Differences

ISSN: 2042-6410

Contact us