Table 3 MSY altered phenotypes with differences in male to female rat strains
Phenotype | Rat treatment | Consomic with significant change | Male to female BN significant | Male to female FHH significant | Male to female SS significant |
|---|---|---|---|---|---|
Plasma lymph abs (E3) | 12 % O2, 0.4 % salt, male | FHH-YBN/Mcwi | No | Yes | – |
Plasma segmented neutrophils (E3) | 12 % O2, 0.4 % salt, male | FHH-YBN/Mcwi | No | Yes | – |
Plasma mean corpuscular hemoglobin content (pg) | 12 % O2, 0.4 % salt, male | FHH-YBN/Mcwi | Yes | No | – |
Plasma mean corpuscular volume (fL) | 12 % O2, 0.4 % salt, male | FHH-YBN/Mcwi | Yes | No | – |
Plasma red blood cell (E6/μL) | 21 % O2, 0.4 % salt, male | FHH-YBN/Mcwi | Yes | No | – |
Pre-ischemic heart wet weight (g) | 12 % O2, 0.4 % salt, male | FHH-YBN/Mcwi | Yes | No | – |
Pre-ischemic heart wet weight (g) | 21 % O2, 0.4 % salt, male | FHH-YBN/Mcwi | Yes | No | – |
Pre-ischemic left ventricle developed pressure (mmHg) | 12 % O2, 0.4 % salt, male | FHH-YBN/Mcwi | Yes | No | – |
Pre-ischemic left ventricle systolic pressure (mmHg) | 12 % O2, 0.4 % salt, male | FHH-YBN/Mcwi | Yes | No | – |
Methacholine ED50 (mg/kg) | 21 % O2, 0.4 % salt, male | FHH-YBN/Mcwi | Yes | No | – |
Dilator response to acetylcholine EC50 (E-7 mole) | 21 % O2, 0.4 % salt, male | FHH-YBN/Mcwi | Yes | No | – |
Dilator response to acetylcholine Log EC50 (Log molar) | 21 % O2, 0.4 % salt, male | FHH-YBN/Mcwi | Yes | No | – |
Plasma alk phos (U/L) | 21 % O2, 0.4 % salt, male | FHH-YBN/Mcwi | Yes | Yes | – |
Plasma globulin (g/dL) | 21 % O2, 0.4 % salt, male | FHH-YBN/Mcwi | Yes | Yes | – |
Plasma hematocrit (%) | 21 % O2, 0.4 % salt, male | FHH-YBN/Mcwi | Yes | Yes | – |
Plasma hemoglobin (g/dL) | 21 % O2, 0.4 % salt, male | FHH-YBN/Mcwi | Yes | Yes | – |
Plasma phosphorus (mg/dL) | 21 % O2, 0.4 % salt, male | FHH-YBN/Mcwi | Yes | Yes | – |
Plasma total protein (g/dL) | 21 % O2, 0.4 % salt, male | FHH-YBN/Mcwi | Yes | Yes | – |
Plasma white blood cell count (E3/μL) | 12 % O2, 0.4 % salt, male | FHH-YBN/Mcwi | Yes | Yes | – |
Ischemic peak contracture (mmHg) | 12 % O2, 0.4 % salt, male | FHH-YBN/Mcwi | Yes | Yes | – |
Body weight (kg) | 12 % O2, 0.4 % salt, male | FHH-YBN/Mcwi | Yes | Yes | – |
Body weight (kg) | 12 % O2, 0.4 % salt, male | FHH-YBN/Mcwi | Yes | Yes | – |
Body weight (kg) | 21 % O2, 0.4 % salt, male | FHH-YBN/Mcwi | Yes | Yes | – |
Lung dry wt (g)/body wt. (kg) ratio (g/kg) | 21 % O2, 0.4 % salt, male | FHH-YBN/Mcwi | Yes | Yes | – |
Hematocrit (%) | 21 % O2, 0.4 % salt, male | FHH-YBN/Mcwi | Yes | Yes | – |
Rt ventricle/left ventricle weight ratio (w/w ratio) | 12 % O2, 0.4 % salt, male | FHH-YBN/Mcwi | Yes | Yes | – |
Body weight | 21 % O2, 0.4 % salt, male | FHH-YBN/Mcwi | Yes | Yes | – |
r @flow = 100 ml/min/g (mmHg × min × kg × ml−1) | 21 % O2, 0.4 % salt, male | SS-YBN/Mcwi | No | – | Yes |
Plasma red blood cell (E6/μL) | 21 % O2, 0.4 % salt, male | SS-YBN/Mcwi | Yes | – | No |
Dilator response to acetylcholine EC50 (E-7 mole) | 21 % O2, 0.4 % salt, male | SS-YBN/Mcwi | Yes | – | No |
Dilator response to acetylcholine Log EC50 (Log molar) | 21 % O2, 0.4 % salt, male | SS-YBN/Mcwi | Yes | – | No |
Plasma calcium (mg/dL) | 21 % O2, 0.4 % salt, male | SS-YBN/Mcwi | Yes | – | Yes |
Plasma globulin (g/dL) | 21 % O2, 0.4 % Salt, Male | SS-YBN/Mcwi | Yes | – | Yes |
Plasma globulin (g/dL) | 12 % O2, 0.4 % salt, male | SS-YBN/Mcwi | Yes | – | Yes |
Plasma hematocrit (%) | 12 % O2, 0.4 % salt, male | SS-YBN/Mcwi | Yes | – | Yes |
Plasma hemoglobin (g/dL) | 21 % O2, 0.4 % salt, male | SS-YBN/Mcwi | Yes | – | Yes |
Plasma hemoglobin (g/dL) | 12 % O2, 0.4 % salt, male | SS-YBN/Mcwi | Yes | – | Yes |
Plasma mono abs (E3) | 21 % O2, 0.4 % salt, male | SS-YBN/Mcwi | Yes | – | Yes |
Plasma potassium (mmol/L) | 21 % O2, 0.4 % salt, male | SS-YBN/Mcwi | Yes | – | Yes |
Plasma red blood cell (E6/μL) | 12 % O2, 0.4 % Salt, Male | SS-YBN/Mcwi | Yes | – | Yes |
Plasma total protein (g/dL) | 12 % O2, 0.4 % salt, male | SS-YBN/Mcwi | Yes | – | Yes |
Ischemic time to onset of contracture (s) | 12 % O2, 0.4 % salt, male | SS-YBN/Mcwi | Yes | – | Yes |
Ischemic time to peak contracture (s) | 12 % O2, 0.4 % salt, male | SS-YBN/Mcwi | Yes | – | Yes |
Pre-ischemic heart rate (beats/min) | 12 % O2, 0.4 % salt, male | SS-YBN/Mcwi | Yes | – | Yes |
Pre-ischemic heart wet weight (g) | 12 % O2, 0.4 % salt, male | SS-YBN/Mcwi | Yes | – | Yes |
Body weight (kg) | 12 % O2, 0.4 % salt, male | SS-YBN/Mcwi | Yes | – | Yes |
Body weight (kg) | 12 % O2, 0.4 % salt, male | SS-YBN/Mcwi | Yes | – | Yes |
Lung dry wt (g)/body wt. (kg) ratio (g/kg) | 12 % O2, 0.4 % salt, male | SS-YBN/Mcwi | Yes | – | Yes |
Hematocrit (%) | 21 % O2, 0.4 % salt, male | SS-YBN/Mcwi | Yes | – | Yes |
Hematocrit (%) | 12 % O2, 0.4 % salt, male | SS-YBN/Mcwi | Yes | – | Yes |
Body weight (kg) | 21 % O2, 0.4 % salt, male | SS-YBN/Mcwi | Yes | – | Yes |
Rectal temperature after hypercapnia (°C) | 21 % O2, 0.4 % salt, male | SS-YBN/Mcwi | Yes | – | Yes |
% maximum relaxation acetylcholine (%) | 21 % O2, 0.4 % salt, male | SS-YBN/Mcwi | Yes | – | Yes |