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Fig. 3 | Biology of Sex Differences

Fig. 3

From: The phenotypic impact of the male-specific region of chromosome-Y in inbred mating: the role of genetic variants and gene duplications in multiple inbred rat strains

Fig. 3

Characterization of the multiple Sry copies in commonly used rat strains. a Schematic breakdown of the domains found in rat SRY showing the N-terminus (red), HMG box (blue), hinge (green), bridge (magenta), and C-terminal (yellow) domains of the protein. Locations of SNVs that allow for the identification of individual copies based on the known SHR sequence are shown below the schematic. b Protein model of the full rat Sry1 protein bound to DNA (gray). Color scheme from a for the various domains are shown on the model. c Detection of the SNVs for the multiple copies of Sry from the genomic sequence reads for multiple male rat strains (SHR, WKY, FHH, FHL, ACI, SR, SS, and F334). The plus sign represents multiple reads with 100 % homology (red boxes), the minus sign represents those with no positive SNVs detected (no color), and nd are copies of Sry that do not contain SNVs allowing for identification using short reads. df Real-time PCR of Sry from five tissues for WKY (d), SHR (e), or the SHR/y consomic (f)

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