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Fig. 2 | Biology of Sex Differences

Fig. 2

From: The phenotypic impact of the male-specific region of chromosome-Y in inbred mating: the role of genetic variants and gene duplications in multiple inbred rat strains

Fig. 2

Rat MSY genes. a Alignment of the various genes described in this paper onto the RNor 6.0 MSY sequence of Rattus norvegicus. Retroposed genes that align onto the sequence are shown on the top. Ubiquitously expressed genes in the Rat BodyMap dataset are colored in purple while tissue-specific genes are in black. b, c Expression profiling for the F344 Rat BodyMap dataset for Med14Y (b) and Ube2q2Y (c) in multiple tissues of male and female animals. Expression is shown as the number of reads for MSY copy (Med14y/Ube2q2y) divided by X (Med14y) or chromosome 8 (Ube2q2) and Y copies, in such that values of 0.5 are a 50/50 ratio of transcripts from the X/8 and MSYs and a value of 0 is expression from only the X/8-chromosome. Error bars represent the error of four independent RNAseq datasets and asterisk represents a P < 0.05 between male and female rats. d Distribution of SNPs detected in seven male rat strains on the genome. SNP counts on the y-axis of box-and-whisker plot are normalized to the chromosome size in Mb. MSY (red) is shown to have highly elevated number of mutations compared to all other chromosomes

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