High-fat diet impairs spatial memory and hippocampal intrinsic excitability and sex-dependently alters circulating insulin and hippocampal insulin sensitivity

Table 1 Biophysical measures in CA1 pyramidal neurons that were not altered by the high-fat diet (HFD) in young adult male and female rats

	Rats (n)	Neurons (n)	Input resistance (MΩ)	Sag (mV)	Resting potential (mV)
Control male
aCSF	22	23	81.0 ± 2.4	8.3 ± 0.6	−70.2 ± 0.3
Insulin		15	85.9 ± 3.0	10.2 ± 0.1	−66.0 ± 1.3
HFD male
aCSF	14	24	66.7 ± 2.3	8.1 ± 0.6	−67.5 ± 0.6
Insulin		13	64.3 ± 3.5	8.9 ± 1.0	−68.7 ± 0.4
Control female
aCSF	7	14	59.6 ± 3.4	4.6 ± 0.8	−71.6 ± 0.4
Insulin		8	53.6 ± 1.2	7.1 ± 0.9	−66.7 ± 0.6
HFD female
aCSF	14	20	85.5 ± 4.8	6.5 ± 0.5	−70.3 ± 0.4
Insulin		9	87.0 ± 6.9	10.1 ± 2.2	−63.3 ± 1.7

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