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Fig. 8 | Biology of Sex Differences

Fig. 8

From: High-fat diet impairs spatial memory and hippocampal intrinsic excitability and sex-dependently alters circulating insulin and hippocampal insulin sensitivity

Fig. 8

Sex- and diet-dependent effects of insulin were observed in measures of spike frequency accommodation. In neurons from CD a males and c females, the bath application of insulin did not alter accommodation, with no significant change in firing seen (b, d). Accommodation of HFD male neurons (a) was also unaffected, with no significant change in firing in the presence of insulin (b). In neurons from HFD females, the bath application of insulin (c) actually reduced accommodation, with a significant increase in action potential firing to a sustained depolarizing pulse observed (d). Again, while the HFD did not alter insulin sensitivity in males, it enhanced insulin sensitivity in females. ****p < 0.0001

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