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Fig. 7 | Biology of Sex Differences

Fig. 7

From: High-fat diet impairs spatial memory and hippocampal intrinsic excitability and sex-dependently alters circulating insulin and hippocampal insulin sensitivity

Fig. 7

Diet-dependent responses to bath application of 12.5 nM insulin in CA1 pyramidal neurons from female rats. a Averaged AHP traces are shown from both CD neurons and HFD neurons. b Bath application of insulin had no effect on peak AHP amplitudes in CD neurons but significantly reduced peak AHPs in HFD neurons. c While AHP durations were significantly reduced by insulin in CD neurons, significantly larger reductions were observed in HFD neurons. d Both mAHP and sAHP measures were significantly reduced by insulin in neurons from CD rats (black bars at left indicate comparisons made). Notably, insulin produced a more effective reduction of mAHPs and sAHPs in neurons from HFD rats (gray bars at left indicate comparisons made), continuing much longer post-burst, i.e., insulin significantly enhanced intrinsic excitability for many seconds in neurons from female HFD rats. Unlike in males, where HFD neurons lost insulin sensitivity on multiple measures, insulin sensitivity of AHPs actually increased in neurons from HFD female rats. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001

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