Skip to main content


Fig. 4 | Biology of Sex Differences

Fig. 4

From: High-fat diet impairs spatial memory and hippocampal intrinsic excitability and sex-dependently alters circulating insulin and hippocampal insulin sensitivity

Fig. 4

Further evidence of diet-induced reductions in intrinsic excitability is seen in measures of spike-frequency accommodation of ventral CA1 pyramidal neurons. Representative examples of accommodation of male neurons (a) and female neurons (c) from rats fed the two diets for 15 weeks are shown. Significantly increased accommodation (i.e., decreased action potential firing) to a sustained depolarizing pulse was observed in both male (b) and female (d) HFD CA1 neurons. **p < 0.01; ***p < 0.001

Back to article page