Fig. 3
From: Sex and estrogens alter the action of glucagon-like peptide-1 on reward
Central estrogen blockade attenuates the effects of Ex4 on food-motivated behavior. Concurrent administration of the selective estrogen antagonist ICI and Ex4 attenuated the reduction in sucrose rewards earned in females (c) and males (a) compared to Ex4 treatment alone, although this effect did not reach significance. Reduction of active lever presses for sucrose was also attenuated in both sexes after ICI treatment (b, d). The number of sucrose rewards earned for males and females combined was reduced after central Ex4 injection (e); this effect was attenuated after ICI treatment. Combined results for males and females also demonstrate a significant reduction in lever presses for sucrose after central GLP-1R stimulation; attenuation by the ICI treatment did not reach statistical significance (f). Data are expressed as mean ± SEM. n = 10 (females) and 18 (males) per treatment group. *p < 0.05, **p < 0.01, ****p < 0.0001