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Table 1 BDNF, general characteristics, thrombocyte measures

From: Serum brain-derived neurotrophic factor (BDNF) is not regulated by testosterone in transmen

  Baseline After 12 months  
Mean S.E.M. Mean S.E.M. p
ENIGI transmen
 General characteristics
  Age (years) 29.1 1.8    
  BMI (kg/m2) 24.2 1.0 25.2 0.9 0.016
  Weight (kg) 66.5 3.1 69.8 3.0 0.007
  Waist (cm) 77.4 2.6 79.8 2.5 n.s.
 Laboratory measures
  BDNF (pg/ml) 5635.1 291.0 5573.4 302.2 n.s.
  FSH (U/L) 6.2 1.5 4.5 2.1 n.s.
  LH (U/L) 8.3 1.6 10.4 4.8 n.s.
  Estradiol (pg/mL) 116.5 14.5 51.6 8.7 0.002
  Testosterone total (ng/dL) 42.1 8.4 653.3 44.2 <0.001
  Testosterone free (nmol/L) 0.4 0.1 13.6 1.2 <0.001
  SHBG (nmol/L) 78.0 8.9 36.2 2.7 <0.001
 Lifestyle
  Sports index 2.9 0.9 2.8 0.9 n.s.
  Work index 2.8 0.9 3.0 0.9 n.s.
  Freetime index 2.8 0.9 3.0 0.9 n.s.
  N % N %  
  Current smoking 7 24.1 3 10.2 n.s.
  Baseline 3–7 months 8–18 months  
  Mean S.E.M. Mean S.E.M. Mean S.E.M.  
MPIP transmen
 General characteristics        
  Age (years) 27.2 0.6      
  BMI (kg/m2) 23.6 0.8 24.8 0.8 24.9 0.8 <0.001
 Laboratory measures
  FSH (U/L) 6.3 0.6 5.8 0.9 12.8 5.3 n.s.
  LH (U/L) 12.2 2.2 5.9 1.5 9.8 3.3 0.01
  Estradiol (pg/mL) 113.2 17.5 129.3 42.8 66.0 11.2 0.022
  Testosterone total (nmol/L) 3.0 0.8 24.3 12.8 2.5 3.2 <0.001
 Lifestyle
  Current smoking N % N % N %  
   Yes 6 15.8 5 13.2 4 10.5 n.s
   No 32 84.2 28 73.7 28 73.7 n.s.
   Not documented    5 13.2 6 15.8 n.s
 Thrombocyte measures Mean S.E.M. Mean S.E.M. Mean S.E.M.  
  Thrombocyte count (10^9/l) 270.3 11.4 270.1 11.5 277.6 26.3 n.s.
  Mean thrombocyte volume (fl) 10.3 0.2 10.4 0. 2 10.4 0.2 n.s.
  1. ENIGI European Network for the Investigation of Gender Incongruence, BDNF brain-derived neurotrophic factor, MPIP Max Planck Institute of Psychiatry
  2. Twelve months of CSH resulted in significant changes in sex hormones in both cohorts. In contrast to our initial hypothesis, we did however not observe any statistically significant effect of the treatment on BDNF levels in transmen
  3. P-values in italic indicate a significant difference