Interaction between neonatal maternal deprivation and serum leptin levels on metabolism, pubertal development, and sexual behavior in male and female rats

Table 1 mRNA levels of puberty-related genes in rostral (HTr) and medial basal hypothalamus (MBH)

	Sex	CoVh	CoLept	MDVh	MDLept
Kiss1 HTr	M	100 ± 8.0	95.6 ± 16.0	109.7 ± 9.0	114.4 ± 25.0
Kiss1 HTr	F	438.4 ± 146.2^a	467.1 ± 109.8^a	506.8 ± 84.3^a	319.2 ± 45.6^a
Kiss1 MBH	M	100 ± 8.0	126.3 ± 12.9	116.4 ± 8.7	128.0 ± 19.5
Kiss1 MBH	F	192.0 ± 22.2^a	185.5 ± 33.6^a	172.1 ± 18.8^a	215.6 ± 31.5^a
Gpar54 HTr	M	100 ± 9.2	95.4 ± 6.6	102.5 ± 6.3	92.2 ± 12.3
Gpar54 HTr	F	123.0 ± 12.2	100.8 ± 6.3	100.8 ± 6.1	94.8 ± 4.9
Gpar54 MBH	M	100 ± 8.0	99.4 ± 3.9	103.9 ± 5.0	111.9 ± 9.6
Gpar54 MBH	F	119.9 ± 4.1	104.0 ± 5.5	112.6 ± 16.0	104.0 ± 7.3
Rfrp HTr	M	100 ± 43.6	17.0 ± 3.4	31.7 ± 6.4	39.8 ± 15.8
Rfrp HTr	F	49.3 ± 11.4	39.0 ± 12.3	88.6 ± 26.1	90.8 ± 38.7
Rfrp MBH	M	100 ± 12.9	107.8 ± 13.8	95.1 ± 10.8	117.2 ± 13.7
Rfrp MBH	F	104.9 ± 7.0	110.5 ± 18.6	112.0 ± 11.5	109.9 ± 6.0
Nprffr1 HTr	M	100 ± 8.1	110.0 ± 5.4	100.1 ± 4.0	106.7 ± 8.9
Nprffr1 HTr	F	107.1 ± 11.2	119.7 ± 4.7	98.3 ± 5.6	94.0 ± 12.1
Nprffr1 MBH	M	100 ± 12.8	129.2 ± 7.9	110.6 ± 8.2	115.9 ± 7.5
Nprffr1 MBH	F	107.4 ± 5.1	116.1 ± 10.7	100 ± 5.8	108.6 ± 15.4

Data are expressed as mean ± SEM and normalized to control (Co) values. Co and maternal deprivation (MD) male (M) and female (F) rats with leptin treatment (Lept) or vehicle (Vh) from postnatal day (PND) 9 to PND13. n = 5–6 per experimental group
^aMain effect of sex; three-way ANOVA

ISSN: 2042-6410