TY - JOUR AU - Posillico, Caitlin K. AU - Terasaki, Laurne S. AU - Bilbo, Staci D. AU - Schwarz, Jaclyn M. PY - 2015 DA - 2015/12/12 TI - Examination of sex and minocycline treatment on acute morphine-induced analgesia and inflammatory gene expression along the pain pathway in Sprague–Dawley rats JO - Biology of Sex Differences SP - 33 VL - 6 IS - 1 AB - In addition to its classical effects on opioid receptors, morphine can activate glia and stimulate the production of pro-inflammatory immune molecules which in turn counteract the analgesic properties of morphine. We hypothesized that decreased morphine analgesia in females may be the result of exaggerated microglial activation in brain regions critical for analgesia. SN - 2042-6410 UR - https://doi.org/10.1186/s13293-015-0049-3 DO - 10.1186/s13293-015-0049-3 ID - Posillico2015 ER -